Skip to main content

Advertisement

SpringerLink
Log in

Preoperative Use of a Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer

  • ASO Research Letter
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Kreamer KM. Immune checkpoint blockade: a new paradigm in treating advanced cancer. J Adv Pract Oncol. 2014;5:418–31.

    PubMed  PubMed Central  Google Scholar 

  2. Vonderheide RH, Domchek SM, Clark AS. Immunotherapy for breast cancer: what are we missing? Clin Cancer Res. 2017;23:2640–6.

    Article  Google Scholar 

  3. Gaynor N, Crown J, Collins DM. Immune checkpoint inhibitors: key trials and an emerging role in breast cancer. Semin Cancer Biol. 2020. https://doi.org/10.1016/j.semcancer.2020.06.016.

    Article  PubMed  Google Scholar 

  4. Huang AC, Postow MA, Orlowski RJ, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017;545:60–5.

    Article  CAS  Google Scholar 

  5. Jagodinsky JC, Harari PM, Morris ZS. The promise of combining radiation therapy with immunotherapy. Int J Radiat Oncol Biol Phys. 2020;108:6–16.

    Article  Google Scholar 

  6. Maity A, Mick R, Huang AC, et al. A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. Br J Cancer. 2018;119:1200–7.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Emily A. Verbus MD, Alexander J. Rossi MD & Jonathan M. Hernandez MD

  2. Rena Rowan Breast Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Amy S. Clark MD, MSCE, Neil K. Taunk MD, MSCTS, Anupma Nayak MD & Julia C. Tchou MD, PhD

  3. Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Amy S. Clark MD, MSCE

  4. Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Neil K. Taunk MD, MSCTS

  5. Department of Anatomic Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Anupma Nayak MD

  6. Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Julia C. Tchou MD, PhD

Authors
  1. Emily A. Verbus MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexander J. Rossi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amy S. Clark MD, MSCE
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neil K. Taunk MD, MSCTS
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anupma Nayak MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jonathan M. Hernandez MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Julia C. Tchou MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jonathan M. Hernandez MD or Julia C. Tchou MD, PhD.

Ethics declarations

Disclosure

The authors declare they have no conflicts of interest and nothing to disclose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 166 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Verbus, E.A., Rossi, A.J., Clark, A.S. et al. Preoperative Use of a Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer. Ann Surg Oncol 29, 1530–1532 (2022). https://doi.org/10.1245/s10434-021-10987-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-021-10987-y

Search

Navigation