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Surgery of the Primary Tumor in De Novo Metastatic Breast Cancer Confers No Survival Benefit

  • Breast Oncology
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References

  1. Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer? Surgery. 2002;132:620–6 (discussion 626–7).

    Article  Google Scholar 

  2. Badwe R, Hawaldar R, Nair N, et al. Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial. Lancet Oncol. 2015;16:1380–8.

    Article  Google Scholar 

  3. Soran A, Ozmen V, Ozbas S, et al. Randomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: protocol MF07-01. Ann Surg Oncol. 2018;25:3141–9.

    Article  Google Scholar 

  4. Khan SA, Zhao F, Solin LJ, et al. A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: a trial of the ECOG-ACRIN Research Group (E2108). J Clin Oncol. 2020;38(18 Suppl):LBA2–5.

    Article  Google Scholar 

  5. Bjelic-Radisic V, Fitzal F, Knauer M, Steger G, Egle D, Greil R, et al. Primary surgery versus no surgery in synchronous metastatic breast cancer: patient-reported quality-of-life outcomes of the prospective randomized multicenter ABCSG-28 Posytive Trial. BMC Cancer. 2020;20(1):392. https://doi.org/10.1186/s12885-020-06894-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Reinhorn D, Mutai R, Yerushalmi R, Moore A, Amir E, Goldvaser H. Locoregional therapy in de novo metastatic breast cancer: systemic review and meta-analysis. Breast. 2021;58:173–81.

    Article  Google Scholar 

  7. Stahl K, Wong W, Dodge D, et al. Benefits of surgical treatment of stage IV breast cancer for patients with known hormone receptor and HER2 status. Ann Surg Oncol. 2021;28:2646–58.

    Article  Google Scholar 

  8. Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol. 2015;1:1325–32.

    Article  Google Scholar 

  9. Fisher B, Gunduz N, Coyle J, Rudock C, Saffer E. Presence of a growth-stimulating factor in serum following primary tumor removal in mice. Cancer Res. 1989;49:1996–2001.

    CAS  PubMed  Google Scholar 

  10. Fisher B, Fisher ER. Experimental evidence in support of the dormant tumor cell. Science. 1959;130:918–9.

    Article  CAS  Google Scholar 

  11. O’Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994;79:315–28.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Surgical Oncology, Breast Services, Tata Memorial Centre, Mumbai, India

    Sridevi Murali-Nanavati MS (Gen Surg), HBNI fellow in Breast Oncology (TMH), Nita S. Nair DNB (Gen Surg), MRCS (Ed), MCh (Surg Onco) & Rajendra Badwe MS (Gen Surg)

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  1. Sridevi Murali-Nanavati MS (Gen Surg), HBNI fellow in Breast Oncology (TMH)
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  2. Nita S. Nair DNB (Gen Surg), MRCS (Ed), MCh (Surg Onco)
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  3. Rajendra Badwe MS (Gen Surg)
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Correspondence to Sridevi Murali-Nanavati MS (Gen Surg), HBNI fellow in Breast Oncology (TMH).

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Murali-Nanavati, S., Nair, N.S. & Badwe, R. Surgery of the Primary Tumor in De Novo Metastatic Breast Cancer Confers No Survival Benefit. Ann Surg Oncol 28 (Suppl 3), 787–788 (2021). https://doi.org/10.1245/s10434-021-10887-1

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  • DOI: https://doi.org/10.1245/s10434-021-10887-1

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