This paper is independent research funded by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC), the Cancer Research UK (CRUK) Imperial Centre, and the Imperial Confidence in Concept (ICiC) Joint Translational Fund (Imperial College’s Medical Research Council [MRC] Confidence in Concept fund and the Engineering and Physical Sciences Research Council [EPSRC] Impact Acceleration Account scheme). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Maria Leiloglou would like to acknowledge the support by the Greek Foundation for Education and European Culture (IPEP).