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The role of overall tumor burden (TB) in intrahepatic cholangiocarcinoma (ICC) remains poorly defined. In our recently published article (https://doi.org/10.1245/s10434-020-09393-7), we demonstrated that TB dictated prognosis among patients with resectable ICC. In particular, TB was independently associated with both overall survival (medium-TB: HR = 1.40, 95% confidence interval [CI] 1.14–1.71; high-TB: HR = 1.89, 95% CI 1.46–2.45) and disease-free survival (medium-TBS, HR = 1.61, 95% CI 1.33–1.96; high-TB: HR = 2.03, 95% CI 1.56–2.64) following ICC resection. Adjuvant chemotherapy was associated with a greater survival among patients with high TB. TB may be used as a tool to help guide post-resection treatment strategies.
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Tsilimigras, D.I., Pawlik, T.M. ASO Visual Abstract: Tumor Burden Dictates Prognosis Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma: A Tool to Guide Post-Resection Adjuvant Chemotherapy?. Ann Surg Oncol 28, 1981 (2021). https://doi.org/10.1245/s10434-020-09500-8
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DOI: https://doi.org/10.1245/s10434-020-09500-8