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The Landmark Series: Neuroendocrine Tumor Liver Metastases

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver.

Methods

In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as several randomized control trials which have investigated strategies for systemic control of metastatic disease.

Results

Liver-directed surgical approaches and locally ablative procedures are recommended for patients with limited, resectable, and in some cases, nonresectable tumor burden. Angiographic liver-directed techniques, such as transarterial embolization, chemoembolization, and radioembolization, offer another approach for management in patients with liver-predominant disease. Peptide receptor radionuclide therapy is a promising therapy for patients with hepatic and/or extrahepatic metastases. Various systemic medical therapies are also available as adjunct or definitive therapy for patients with metastatic disease.

Conclusions

This article reviews current data regarding management of neuroendocrine liver metastases and highlights areas for future study.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd, AC 1049, Los Angeles, CA, 90048, USA

    Alexandra Gangi MD

  2. Surgical Oncology and Endocrine Surgery, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, 4644 JCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    James R. Howe MD

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Correspondence to James R. Howe MD.

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Gangi, A., Howe, J.R. The Landmark Series: Neuroendocrine Tumor Liver Metastases. Ann Surg Oncol 27, 3270–3280 (2020). https://doi.org/10.1245/s10434-020-08787-x

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