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Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Microinvasive ductal carcinoma (DCISM), defined as DCIS with a focus of invasive carcinoma ≤ 1 mm, can be managed similarly to pure DCIS; however, management of the axilla in DCISM has been a subject of debate. Reports in the literature differ on the utility and necessity of sentinel lymph node biopsy (SLNB) for DCISM. The aim of the present study was to identify risk factors for nodal disease in patients with DCISM, which can help develop a selective approach to SLNB in this patient population.

Methods

The National Cancer Database was used to select patients with DCISM (pT1mi), diagnosed from 2012 to 2015, who underwent SLNB. Multivariable regression analysis was performed to determine associations between sentinel lymph node metastasis and relevant clinical variables.

Results

Our cohort comprised of 2609 patients with pT1mi who underwent SLNB. Of these, 76 (2.9%) were found to have sentinel lymph node metastases on final pathology. Low/intermediate grade tumors were associated with decreased SLN metastasis (OR 0.50, CI 0.28–0.92). Age and receptor status of the tumor did not have a clear association in predicting SLN metastases.

Conclusions

The rate of sentinel node metastases in DCISM is low at only 2.9% in this national study. Tumor grade was identified as influencing the risk of SLN metastases. This information can factor into shared decision-making for SLNB in patients with DCISM.

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Authors and Affiliations

  1. Department of Surgery, Breast Care Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Betty Fan DO FACOS, Jaime A. Pardo MD, Stephanie Serres MD, PhD, Amulya C. Alapati MD, Joanne Szewczyk MD, Alessandra Mele MD & Ted A. James MD, MS FACS

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  1. Betty Fan DO FACOS
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Correspondence to Ted A. James MD, MS FACS.

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Dr. Ted James is a scientific consultant for Perimeter Medical.

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Fan, B., Pardo, J.A., Serres, S. et al. Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer. Ann Surg Oncol 27, 4468–4473 (2020). https://doi.org/10.1245/s10434-020-08606-3

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