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Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Objective

The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).

Methods

For this retrospective cohort study, patients with PMs considered for CRS/HIPEC who underwent DW-MRI for preoperative staging in 2016–2017 were included. The DW-MRI protocol consisted of diffusion-weighted, T2-weighted, and pre- and post-gadolinium T1-weighted imaging of the chest, abdomen, and pelvis. DW-MRI images were evaluated by two independent readers to determine the extent of PMs represented by the Peritoneal Cancer Index (MRI-PCI), as well as extraperitoneal metastases. Cox regression and Kaplan–Meier analysis was performed to determine the prognostic value of DW-MRI for overall and disease-free survival.

Results

Seventy-eight patients were included. CRS/HIPEC was planned for 53 patients and completed in 50 patients (60.5%). Median follow-up after DW-MRI was 23 months (interquartile range 13–24). The MRI-PCI of both readers showed prognostic value for overall survival, independently of whether R1 resection was achieved (hazard ratio [HR] 1.06–1.08; p < 0.05). For the patients who received successful CRS/HIPEC, the MRI-PCI also showed independent prognostic value for disease-free survival for both readers (HR 1.09–1.10; p < 0.05).

Conclusion

The extent of PMs on preoperative DW-MRI is an independent predictor of overall and disease-free survival and should therefore be considered as a non-invasive prognostic biomarker.

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Author notes

  1. Maurits P. Engbersen and Arend G. J. Aalbers contributed equally to this paper.

Authors and Affiliations

  1. Department of Radiology, Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, The Netherlands

    Maurits P. Engbersen MSc, Iris Van‘t Sant-Jansen MD, Jeroen D. R. Velsing MD, Doenja M. J. Lambregts MD, PhD, Regina G. H. Beets-Tan MD, PhD & Max J. Lahaye MD, PhD

  2. Department of Surgery, Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, The Netherlands

    Arend G. J. Aalbers MD & Niels F. M. Kok MD, PhD

  3. GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

    Maurits P. Engbersen MSc & Regina G. H. Beets-Tan MD, PhD

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  1. Maurits P. Engbersen MSc
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Correspondence to Max J. Lahaye MD, PhD.

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Engbersen, M.P., Aalbers, A.G.J., Van‘t Sant-Jansen, I. et al. Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer. Ann Surg Oncol 27, 3516–3524 (2020). https://doi.org/10.1245/s10434-020-08416-7

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  • DOI: https://doi.org/10.1245/s10434-020-08416-7

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