References
Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168(6):960–76.
Yu XN, Chen H, Liu TT, Wu J, Zhu JM, Shen XZ. Targeting the mTOR regulatory network in hepatocellular carcinoma: are we making headway? Biochim Biophys Acta Rev Cancer. 2019;1871(2):379–91.
Jiang XM, Yu XN, Huang RZ, et al. Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2016;142(11):2309–17.
Yu X-N, Zhang G-C, Sun J-L, et al. Enhanced mLST8 expression correlates with tumor progression in hepatocellular carcinoma. Ann Surg Oncol. (2020). https://doi.org/10.1245/s10434-020-08263-6.
Guertin DA, Stevens DM, Thoreen CC, et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006;11(6):859–71.
Hwang Y, Kim LC, Song W, Edwards DN, Cook RS, Chen J. Disruption of scaffolding function of mLST8 selectively inhibits mTORC2 assembly and function and suppresses mTORC2-dependent tumor growth in vivo. Cancer Res. 2019;79:3178–84.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Disclosure
There are no conflicts of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yu, XN., Shen, XZ., Guo, HY. et al. ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma. Ann Surg Oncol 27, 1558–1559 (2020). https://doi.org/10.1245/s10434-020-08275-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1245/s10434-020-08275-2