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Ultrasound-Based Nomogram Identifies Breast Cancer Patients Unlikely to Harbor Axillary Metastasis: Towards Selective Omission of Sentinel Lymph Node Biopsy

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

As tumor biology takes precedence over anatomic staging to determine breast cancer (BC) prognosis, there is growing interest in limiting axillary surgery. There is a need for tools to identify patients at the lowest risk of harboring axillary lymph node (ALN) disease, to determine when omission of sentinel lymph node biopsy (SLNB) may be appropriate. We examined whether a nomogram using preoperative axillary ultrasound (axUS) findings, clinical tumor size, receptor status, and grade to calculate the probability of nodal metastasis (PNM) has value in surgical decision making.

Methods

This was a retrospective analysis of female patients (February 2011–October 2014) with invasive BC who underwent preoperative axUS and axillary surgery. Cases with locally advanced BC, neoadjuvant treatment, or bilateral BC were excluded. PNM was calculated for each case. Using various PNM thresholds, the proportion of cases with ALN metastasis on pathology was examined to determine an optimal PNM cut-point to predict ALN negativity.

Results

Of 357 included patients, 72% were node-negative on surgical staging, and 69 (19.6%) had a PNM < 9.3%. Of these 69 patients, 6 had ALN metastasis on surgical pathology, yielding a false negative rate (FNR) of 8.7% for predicting negative ALN when a PNM threshold of < 9.3% was used.

Conclusion

A nomogram incorporating axUS findings and tumor characteristics identified a sizeable subgroup (19.6%) in whom ALN was predicted to be negative, with an 8.7% FNR. Surgeons can use this nomogram to quantify the probability of ALN metastasis and select patients who may benefit from omitting SLNB.

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Authors and Affiliations

  1. The Rebecca Fortney Breast Center, Anne Arundel Medical Center, Annapolis, MD, USA

    Hanh-Tam Tran MD, Daina Pack MD, Charles Mylander PhD, Laura Martino BS, Martin Rosman MD, Lorraine Tafra MD & Rubie Sue Jackson MD

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  1. Hanh-Tam Tran MD
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  2. Daina Pack MD
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  3. Charles Mylander PhD
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  4. Laura Martino BS
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  5. Martin Rosman MD
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  6. Lorraine Tafra MD
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  7. Rubie Sue Jackson MD
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Correspondence to Rubie Sue Jackson MD.

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Hanh-Tam Tran, Daina Pack, Charles Mylander, Laura Martino, Martin Rosman, Lorraine Tafra, and Rubie Sue Jackson have no financial disclosures to declare.

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Tran, HT., Pack, D., Mylander, C. et al. Ultrasound-Based Nomogram Identifies Breast Cancer Patients Unlikely to Harbor Axillary Metastasis: Towards Selective Omission of Sentinel Lymph Node Biopsy. Ann Surg Oncol 27, 2679–2686 (2020). https://doi.org/10.1245/s10434-019-08164-3

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  • DOI: https://doi.org/10.1245/s10434-019-08164-3

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