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Main Pancreatic Duct to Parenchymal Thickness Ratio at Preoperative Imaging is Associated with Overall Survival in Upfront Resected Pancreatic Cancer

  • Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Pancreatic cancer induces parenchymal atrophy and duct dilation. The aim of this study was to evaluate whether these radiologic modifications are associated with outcomes.

Methods

Upfront pancreaticoduodenectomy patients with available preoperative contrast enhanced CT scan imaging were retrospectively analyzed. Thickness of the pancreas, size of the main pancreatic duct (MPD), and distance of the tumor from the ampulla were assessed. A training cohort was selected, including short- (3–12 months following surgery) and long-term (≥ 36 months) survivors. Identified survival determinants were validated in the overall cohort.

Results

Two-hundred-sixteen patients were analyzed. In the training cohort (N = 118), 68 patients (57.6%) were in the short-term and 50 (42.4%) in the long-term survival group. The short-term survival group had significantly higher CA 19–9 levels (p = 0.027), larger tumors (32.6 ± 12.1 mm vs. 26.5 ± 11.6 mm, p = 0.007), poorer differentiation (p = 0.003), higher rate of R < 1 mm resections (54% vs. 32%, p = 0.008), and reduced receipt of adjuvant chemotherapy (p = 0.020). The MPD-to-pancreatic thickness ratio was significantly lower in the short-term survivors (3.6 ± 6.2 vs. 8.2 ± 12.0, p = 0.016). In the entire cohort, an MPD-to-pancreatic thickness ratio ≥ 3.5 was associated with improved OS [median 33.0 months IQR (19.7–48.1) versus 17 months IQR (14.8–19.2), p = 0.004], and confirmed by a Cox-proportional hazards model independently associated with OS (HR = 0.58; p = 0.009), together with tumor size (HR = 1.02; p =0.012), R1/R2 status (HR = 1.53; p = 0.029), and receipt of adjuvant treatment (HR = 0.61; p = 0.021).

Conclusions

High MPD-to-pancreatic thickness ratio was associated with improved long-term survival in pancreaticoduodenectomy for cancer. Whether these features are related to tumor chronicity, indolent biology, or local growth over metastasis remains to be determined.

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Authors and Affiliations

  1. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Marta Sandini MD, Motaz Qadan MD, Thomas Hank MD, Cristina R. Ferrone MD, Andrew L. Warshaw MD, Keith D. Lillemoe MD & Carlos Fernández-del Castillo MD

  2. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Adrian A. Negreros-Osuna MD, Manuel Patino MD & Dushyant Sahani MD

Authors
  1. Marta Sandini MD
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  2. Adrian A. Negreros-Osuna MD
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  3. Motaz Qadan MD
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  4. Thomas Hank MD
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  5. Manuel Patino MD
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  6. Cristina R. Ferrone MD
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  7. Andrew L. Warshaw MD
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  9. Dushyant Sahani MD
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  10. Carlos Fernández-del Castillo MD
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Correspondence to Carlos Fernández-del Castillo MD.

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Sandini, M., Negreros-Osuna, A.A., Qadan, M. et al. Main Pancreatic Duct to Parenchymal Thickness Ratio at Preoperative Imaging is Associated with Overall Survival in Upfront Resected Pancreatic Cancer. Ann Surg Oncol 27, 1606–1612 (2020). https://doi.org/10.1245/s10434-019-08040-0

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  • DOI: https://doi.org/10.1245/s10434-019-08040-0

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