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Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties

Annals of Surgical Oncology volume 26, pages 3920–3930 (2019)Cite this article

Abstract

Background

Adolescents and young adults (AYAs; age < 40 years) account for less than 2% of breast cancer patients. Therefore, little is known about the tumor characteristics and care provided to AYA patients. This study sought to describe demographic, tumor, and treatment variables among AYA patients.

Methods

The study identified patients ages 15 to 49 years with breast cancer between 2010 and 2015 from the National Cancer Database. Patient and tumor factors were compared using Chi-square tests. Multivariable logistic regression was used to model the effect of age group on treatment while adjusting for confounding variables.

Results

The study identified 46,265 AYA patients with stages 0 to 3 breast cancer and compared them with 169,423 breast cancer patients ages 40 to 49 years. A greater proportion of the AYA patients presented with clinical stage 2 or 3 disease than the adult patients 40 to 49 years old (stage 2 disease: 44.3% vs 29.9%, respectively; stage 3 disease: 14.0% vs 7.7%, respectively; both p < 0.001). A greater proportion of the AYA patients had triple-negative breast cancer (TNBC) or human epidermal growth factor receptor 2-positive (HER2+) cancer than the adult patients (TNBC: 21.2% vs 13.8%, respectively; HER2+: 26.0% vs 18.6%, respectively; both p < 0.001). Among the AYA patients, the very young (ages 15–29 years) had more advanced disease and TNBC or HER2+ disease than the older youth (ages 30 to 39 years). The multivariable analysis showed that the AYA patients were more likely to undergo mastectomy (odds ratio [OR] 2.1) and receive chemotherapy (OR 1.9) than patients in their forties (both p < 0.001).

Conclusion

A greater proportion of the AYA breast cancer patients had more advanced disease and TNBC and HER2+ disease. The AYA patients had higher rates of mastectomy and use of chemotherapy than the adult breast cancer patients, reflecting that more aggressive therapy is recommended or chosen for women in this age group.

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Acknowledgment

The Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery was a substantial contributor of funding to the authors of the project. The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methodology used or the conclusions drawn from these data by the investigator. The authors acknowledge the Mayo Clinic Department of Surgery and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery as substantial contributors of resources to the project.

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Affiliations

  1. Department of Surgery, Mayo Clinic, Rochester, MN, USA

    Brittany L. Murphy MD, MS, Elizabeth B. Habermann PhD, MPH & Judy C. Boughey MD

  2. The Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA

    Brittany L. Murphy MD, MS & Elizabeth B. Habermann PhD, MPH

  3. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

    Courtney N. Day BS, Tanya L. Hoskin MS & Elizabeth B. Habermann PhD, MPH

Authors
  1. Brittany L. Murphy MD, MS
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  2. Courtney N. Day BS
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  3. Tanya L. Hoskin MS
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  4. Elizabeth B. Habermann PhD, MPH
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  5. Judy C. Boughey MD
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Corresponding author

Correspondence to Judy C. Boughey MD.

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Murphy, B.L., Day, C.N., Hoskin, T.L. et al. Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties. Ann Surg Oncol 26, 3920–3930 (2019). https://doi.org/10.1245/s10434-019-07653-9

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  • DOI: https://doi.org/10.1245/s10434-019-07653-9