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Annals of Surgical Oncology

, Volume 26, Issue 10, pp 3232–3239 | Cite as

Are we Overtreating Hormone Receptor Positive Breast Cancer with Neoadjuvant Chemotherapy? Role of OncotypeDx® for Hormone Receptor Positive Patients Undergoing Neoadjuvant Chemotherapy

  • Olga Kantor
  • Ermilo Barrera
  • Katherine Kopkash
  • Catherine Pesce
  • Ermilo Barrera
  • David J. Winchester
  • Katharine YaoEmail author
Breast Oncology
  • 161 Downloads

Abstract

Background

The utilization of OncotypeDx in the setting of neoadjuvant chemotherapy (NCT) is not well defined. The objective of this study was to determine what proportion of hormone receptor (HR)-positive patients undergoing NCT would not benefit from chemotherapy based on OncotypeDx recurrence scores (RS) and predictors of a high RS as defined by the TAILORx trial.

Methods

The National Cancer Data Base was used to identify patients with unilateral clinical stage I–III HR+/Her2− breast cancer who had an OncotypeDx score and who had undergone NCT. Patients undergoing adjuvant chemotherapy were used as a comparison group.

Results

Of 307,666 patients, 41.8% had testing with OncotypeDx. Of these, 76.6% had no chemotherapy, 22.3% adjuvant chemotherapy, and 1.1% NCT. OncotypeDx testing in NCT patients increased from 4.9% in 2010 to 8.2% in 2015. Of NCT patients with OncotypeDx testing, 11.6% had RS < 11, 44.4% RS 11–25, and 43.9% RS > 25. In patients age ≤ 50 years, 14.5% had RS < 11, 12.4% RS 11–15, 31.4% RS 16–25, and 41.7% RS > 25. Predictors of RS > 25 on multivariable analysis included grade 3 tumors (odds ratio [OR] 3.83) and PR-negative tumors (OR 5.26) but not clinical T or N stage (p > 0.05).

Conclusions

More than half of patients with OncotypeDx testing are being overtreated with NCT, and a third of younger patients are being overtreated. Predictors of a high RS are reliably available at core biopsy, suggesting an application of OncotypeDx in determining the need for NCT for some HR-positive breast cancers.

Notes

References

  1. 1.
    Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004;351(27):2817–26.CrossRefGoogle Scholar
  2. 2.
    Paik S, Tang G, Shak S, et al. Gene expression and benefit of chemotherapy in women with node negative, estrogen receptor-positive breast cancer. J Clin Oncol. 2006;24(23):3726–34.CrossRefGoogle Scholar
  3. 3.
    Dowsett M, Cuzick J, Wale C, et al. Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study. J Clin Oncol. 2010;28(11):1829–34.CrossRefPubMedGoogle Scholar
  4. 4.
    Albain KS, Barlow WE, Shak S, et al. Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol. 2010;11(1):55–65.CrossRefPubMedGoogle Scholar
  5. 5.
    Sparano JA, Gray RJ, Makower DF, et al. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. N Engl J Med. 2018;379(2):111–21.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Breast Cancer. Version 1. 2019. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed 14 April 2019.
  7. 7.
    American Joint Committee on Cancer. AJCC cancer staging manual, 8th edn. Chicago, IL: Springer; 2017.Google Scholar
  8. 8.
    Bhutiani N, Egger ME, Ajkay N, Scoggins CR, Martin RC 2nd, McMasters KM Multigene signature panels and breast cancer therapy: patterns of use and impact on clinical decision making. J Am Coll Surg. 2018;226(4):406–12.CrossRefPubMedGoogle Scholar
  9. 9.
    Anderson J, Shak S, Millward C, Labusch M, Chen I, Watson D, Baehner F. Molecular characterization of breast cancer core biopsy specimens by gene expression analysis using standardized quantitative RT-PCR. Cancer Res. 2009;69(24 suppl):6021.Google Scholar
  10. 10.
    Gianni L, Zambetti M, Clark M, et al. Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer. J Clin Oncol. 2005;23(29):7265–77.CrossRefGoogle Scholar
  11. 11.
    Chang JC, Makris A, Gutierrez MC, et al. Gene expression patterns in formalin-fixed, paraffin-embedded core biopsies predict docetaxel chemosensitivity in breast cancer patients. Breast Cancer Res Treat. 2008;108(2):233–40.CrossRefGoogle Scholar
  12. 12.
    Yardley DA, Peacock NW, Shastry M, et al. A phase II trial of ixabepilone and cyclophosphamide as neoadjuvant therapy for patients with Her2-negative breast cancer: correlation of pathologic complete response with the 21-gene recurrence score. Breast Cancer Res Treat. 2015;154(2):299–308.CrossRefGoogle Scholar
  13. 13.
    Soran A, Bhargava R, Johnson R, et al. The impact of OncotypeDx® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer. Breast Dis. 2016;36(2–3):65–71.CrossRefGoogle Scholar
  14. 14.
    Bear HD, Wan W, Robidoux A, et al. Using the 21-gene assay from needle biopsies to choose neoadjuvant therapy for breast cancer: a multicenter trial. J Surg Oncol. 2017;115(8):917–23.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Iwata H, Masuda N, Yamamoto Y, et al. Validation of the 21-gene test as a predictor of clinical response to neoadjuvant hormonal therapy for ER+, Her2-negative breast cancer: the TransNEOS study. Breast Cancer Res Treat. 2019;173(1):123–33.CrossRefPubMedGoogle Scholar
  16. 16.
    Bilimoria KY, Bentrem DJ, Stewart AK, Winchester DP, Ko CY. Comparison of commission on cancer-approved and -nonapproved hospitals in the United States: implications for studies that use the National Cancer Data Base. J Clin Oncol. 2009;27:4177–81.CrossRefGoogle Scholar
  17. 17.
    American Joint Committee on Cancer. AJCC cancer staging manual, 7th edn. Chicago, IL: Springer; 2010.CrossRefGoogle Scholar
  18. 18.
    Pease AM, Riba LA, Gruner RA, Tung NM, James TA. OncotypeDx® recurrence score as a predictor of response to neoadjuvant chemotherapy. Ann Surg Oncol. 2019;26(2):366–71.CrossRefPubMedGoogle Scholar

Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Olga Kantor
    • 1
  • Ermilo Barrera
    • 2
    • 3
  • Katherine Kopkash
    • 2
    • 3
  • Catherine Pesce
    • 2
    • 3
  • Ermilo Barrera
    • 2
    • 3
  • David J. Winchester
    • 2
    • 3
  • Katharine Yao
    • 2
    • 3
    Email author
  1. 1.Department of SurgeryUniversity of ChicagoChicagoUSA
  2. 2.Division of Surgical Oncology, Department of SurgeryNorthShore University HealthSystemEvanstonUSA
  3. 3.Pritzker School of MedicineUniversity of ChicagoChicagoUSA

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