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Long-Term Outcomes After Surgical Resection for Pleural Dissemination of Thymoma

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Cases of thymoma with pleural dissemination are occasionally encountered, and their management is difficult. Some reports have noted that surgical treatment for dissemination is effective, although the long-term results and clinical course details remain unclear. The current study investigated the short- and long-term outcomes of surgical resection of pleural dissemination.

Methods

A retrospective review examined the medical records for 38 patients who underwent surgical resection for pleural dissemination occurring synchronously with a primary thymoma or metachronously after complete surgical resection of a primary thymoma between 1996 and 2017 at the authors’ institution. Clinical characteristics and prognostic factors were analyzed.

Results

The patients were classified into synchronous (n = 21) and metachronous (n = 17) groups. The 10-year overall survival rate was 59% for the synchronous group and 88% for the metachronous group. The median follow-up period for all the patients was 61 months (range 4–225 months). No perioperative deaths occurred. For all the patients, the 5- and 10-year overall survival rates were respectively 91% and 82%, and the 5- and 10-year relapse-free survival rates were respectively 29% and 19%. A significantly worse prognosis was observed for patients 50 years of age or older than for those younger than 50 years (p = 0.02). For 13 patients who underwent repeat resection for pleural dissemination, the prognosis was better than for those without repeat resection (p < 0.01).

Conclusion

Surgical resection of thymoma with pleural disseminated nodules can be safely performed and provides a favorable long-term outcome. Repeat resection is considered to be effective for achieving a good prognosis.

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Authors and Affiliations

  1. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan

    Kenji Kimura MD, Ryu Kanzaki MD, PhD, Takashi Kanou MD, PhD, Naoko Ose MD, Soichiro Funaki MD, PhD, Masato Minami MD, PhD, Yasushi Shintani MD, PhD & Meinoshin Okumura MD, PhD

  2. Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan

    Toru Kimura MD, PhD

  3. Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Toyonaka, Japan

    Meinoshin Okumura MD, PhD

Authors
  1. Kenji Kimura MD
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  2. Ryu Kanzaki MD, PhD
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  3. Toru Kimura MD, PhD
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  4. Takashi Kanou MD, PhD
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  5. Naoko Ose MD
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  6. Soichiro Funaki MD, PhD
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  7. Masato Minami MD, PhD
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  8. Yasushi Shintani MD, PhD
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  9. Meinoshin Okumura MD, PhD
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Corresponding author

Correspondence to Ryu Kanzaki MD, PhD.

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Supplementary material 1 (DOCX 20 kb)

Supplementary Fig. 1.

The overall survival of all patients (n=38) according to performance of repeat resection for thymoma pleural dissemination. Patients who underwent repeat resection showed a better prognosis than those who did not (p=0.005). (PDF 46 kb)

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Kimura, K., Kanzaki, R., Kimura, T. et al. Long-Term Outcomes After Surgical Resection for Pleural Dissemination of Thymoma. Ann Surg Oncol 26, 2073–2080 (2019). https://doi.org/10.1245/s10434-019-07330-x

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  • DOI: https://doi.org/10.1245/s10434-019-07330-x

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