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Annals of Surgical Oncology

, Volume 25, Issue 1, pp 326–332 | Cite as

Short-Term Outcomes Following Minimally Invasive and Open Esophagectomy: A Population-Based Study from Finland and Sweden

  • Joonas H. Kauppila
  • Olli Helminen
  • Ville Kytö
  • Jarmo Gunn
  • Jesper Lagergren
  • Eero Sihvo
Gastrointestinal Oncology
  • 240 Downloads

Abstract

Background

Population-based studies comparing minimally invasive esophagectomy (MIE) and open esophagectomy (OE) relative to 90-day postoperative mortality are needed.

Objective

The aim of this study was to compare short-term outcomes following these two techniques for esophageal cancer.

Methods

Patients undergoing MIE (n = 217) or OE (n = 1397) for esophageal cancer between 2007 and 2014 were identified from nationwide complete registries in Finland and Sweden. The primary outcome was 90-day mortality, and secondary outcomes were 30-day mortality, length of hospital stay, and 30- and 90-day readmission rate. Results were adjusted for age, sex, comorbidity, tumor histology, surgery year, and country.

Results

Ninety-day mortality rates were 4.1% (n = 9 of 217) for MIE and 6.8% (n = 95 of 1397) for OE; 90-day mortality was halved after MIE [adjusted hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.24–0.99]. There was no difference in 30-day mortality (adjusted HR 0.87, 95% CI 0.29–2.66). Median hospital stay was 15 days for MIE and 16 days for OE (adjusted β −0.17, standard error 0.08, p = 0.030). The 30-day readmission rates were 8.9% after MIE and 12.0% after OE (adjusted HR 0.57, 95% CI 0.34–0.94), while the 90-day readmission rates were 28.8% and 33.6%, respectively, without a statistically significant difference (adjusted HR 0.82, 95% CI 0.61–1.10).

Conclusions

This population-based study from Finland and Sweden revealed lower 90-day mortality, shorter hospital stay, and lower 30-day readmission rates after MIE compared with OE for esophageal cancer. These findings support the use of minimally invasive approaches.

Notes

ACKNOWLEDGEMENT

This study was supported by grants from Sigrid Juselius Foundation (JHK), Orion Research Foundation (JHK), Swedish Research Council (JL), and the Swedish Cancer Society (JL).

Disclosure

Joonas H. Kauppila, Olli Helminen, Ville Kytö, Jarmo Gunn, Jesper Lagergren and Eero Sihvo declare no conflicts of interest.

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Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  1. 1.Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska InstitutetKarolinska University HospitalStockholmSweden
  2. 2.Cancer and Translational Medicine Research Unit, Medical Research Center OuluUniversity of Oulu and Oulu University HospitalOuluFinland
  3. 3.Department of SurgeryCentral Finland Central HospitalJyväskyläFinland
  4. 4.Heart CenterTurku University HospitalTurkuFinland
  5. 5.Research Center of Applied and Preventive Cardiovascular MedicineUniversity of TurkuTurkuFinland
  6. 6.Department of Surgery, Faculty of MedicineUniversity of TurkuTurkuFinland
  7. 7.Division of Cancer StudiesKing’s College London and Guy’s and St Thomas’ NHS Foundation TrustLondonUK

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