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Ultimate Clinical Outcomes of Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term outcome for the uncertain malignant potential (UMP) subtype of AMNs with those of the mucinous adenoma (MA) and mucinous adenocarcinoma (MAC) subtypes.

Methods

In this study, AMNs were classified into three groups (MA, UMP, and MAC), and clinical characteristics, overall survival (OS), and progression-free survival (PFS) were compared among the three groups.

Results

The study included 65 AMN patients (26 MA, 20 UMP, and 19 MAC patients). The median follow-up period was 87 months (range 0.3–311.0) months. The symptoms at diagnosis and the presence of pseudomyxoma peritonei were more common in the MAC group than in the MA group (P = 0.012) or the UMP group (P < 0.001). The 5-year OS rates were 95.5% for the MA group, 93.8% for the UMP group, and 78.3% for the MAC group (P < 0.001), and the 5-year PFS rates were 95.2% for the MA group, 95% for the UMP group, and 36.8% for the MAC group (P < 0.001). Thus, OS and PFS did not differ significantly in the MA and UMP groups (P = 0.884 and 0.345, respectively). In contrast, the OS and PFS of the MAC group were worse than in the MA group (P = 0.017 and <0.001, respectively) or the UMP group (P < 0.001 and 0.001, respectively).

Conclusions

The long-term outcome for UMP tumors is similar to that for MA tumors and significantly better than for MAC tumors.

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Acknowledgement

We thank Jee-yun Ahn, MD, and Sohee Oh, PhD, at the Department of Biostatistics of Seoul National University Boramae Medical Center for statistical advice.

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Authors and Affiliations

  1. Department of Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea

    Rumi Shin MD & Young Jun Chai MD

  2. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

    Rumi Shin MD, Young Jun Chai MD, Ji Won Park MD, Kyu Joo Park MD, PhD & Seung-Yong Jeong MD, PhD

  3. Cancer Research Institute, Seoul National University, Seoul, Korea

    Ji Won Park MD, Kyu Joo Park MD, PhD & Seung-Yong Jeong MD, PhD

  4. Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea

    Ji Won Park MD, Kyu Joo Park MD, PhD & Seung-Yong Jeong MD, PhD

  5. Department of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea

    Mee soo Chang MD, PhD & Jeong Mo Bae MD, PhD

  6. Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea

    Min Jung Kim MD & Byung Kwan Park MD

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  1. Rumi Shin MD
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  2. Young Jun Chai MD
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  3. Ji Won Park MD
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  6. Min Jung Kim MD
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  8. Kyu Joo Park MD, PhD
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  9. Seung-Yong Jeong MD, PhD
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Correspondence to Seung-Yong Jeong MD, PhD.

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Shin, R., Chai, Y.J., Park, J.W. et al. Ultimate Clinical Outcomes of Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential. Ann Surg Oncol 24, 974–982 (2017). https://doi.org/10.1245/s10434-016-5657-6

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  • DOI: https://doi.org/10.1245/s10434-016-5657-6

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