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Annals of Surgical Oncology

, Volume 23, Issue 5, pp 1508–1514 | Cite as

Use of a Magnetic Tracer for Sentinel Lymph Node Detection in Early-Stage Breast Cancer Patients: A Meta-analysis

  • Mediget Teshome
  • Caimiao Wei
  • Kelly K. Hunt
  • Alastair Thompson
  • Kelly Rodriguez
  • Elizabeth A. MittendorfEmail author
Breast Oncology

Abstract

Background

Sentinel lymph node (SLN) dissection involves lymphatic mapping and selective removal of clinically negative lymph nodes at highest risk for harboring metastases. Lymphatic mapping is most often performed using radioisotope with or without blue dye (standard tracers). Sienna+®, a superparamagnetic iron oxide that can be detected using the Sentimag® magnetometer, is an alternative mapping agent to identify SLNs that has been investigated in five clinical trials. This meta-analysis was performed to determine if Sienna+® is non-inferior for SLN detection when compared to standard tracers.

Methods

Five clinical trials comparing Sienna+® to a standard technique were identified, and data from these studies were used to determine the agreement by Kappa statistic between Sienna+® and standard tracers in identifying SLNs and malignant SLNs. The trials included 1683 SLNs identified in 804 patients. Data from the studies were imbalanced, therefore additional agreement indices were utilized to compare techniques. The estimated difference between the techniques was analyzed and a margin of ≤5 % was used to determine non-inferiority.

Results

Agreement between the Sienna+® and standard tracers was strong for SLN detection by patient [prevalence-adjusted bias-adjusted kappa (PABAK) 0.94, 95 % confidence interval (CI) 0.89–0.98], moderate to substantial for SLN detection by node (PABAK 0.68, 95 % CI 0.54–0.82), and strong for the detection of malignant SLNs by patient (PABAK 0.89, 95 % CI 0.84–0.95). Sienna+® demonstrated non-inferiority compared with standard tracers.

Conclusions

The Sienna+® mapping agent is non-inferior to the standard method for SLN detection in patients with clinically node-negative breast cancer.

Keywords

Sentinel Lymph Node Lymphatic Mapping Positive Sentinel Lymph Node Sentinel Lymph Node Dissection Sentinel Lymph Node Detection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosure

The University of Texas MD Anderson Cancer Center received an unrestricted educational grant from Endomagnetics, Inc. to support the statistical analyses for this study. Mediget Teshome, Caimiao Wei, Kelly K. Hunt, Alastair Thompson, Kelly Rodriguez, and Elizabeth A. Mittendorf have no additional conflicts of interest to report.

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Copyright information

© Society of Surgical Oncology 2016

Authors and Affiliations

  • Mediget Teshome
    • 1
  • Caimiao Wei
    • 2
  • Kelly K. Hunt
    • 1
  • Alastair Thompson
    • 1
  • Kelly Rodriguez
    • 1
  • Elizabeth A. Mittendorf
    • 1
    Email author
  1. 1.Department of Breast Surgical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of BiostatisticsThe University of Texas MD Anderson Cancer CenterHoustonUSA

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