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Long-Term Follow-Up Evaluation of 68 Patients with Uveal Melanoma Liver Metastases Treated with Isolated Hepatic Perfusion

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

This report describes the outcomes and long-term follow-up data from all isolated hepatic perfusions (IHPs) performed at a single institution in Sweden between the years 1989 and 2013 for patients with isolated uveal melanoma metastases.

Methods

A total of 68 patients (median age, 61 years) were treated consecutively at Sahlgrenska University Hospital. Of the 68 patients, 67 % had fewer than 10 tumors. The median diameter of the largest lesion was 2.5 cm. The patients underwent IHP with either melphalan alone or the addition of either tumor necrosis factor-alpha or cisplatin. The response was assessed after 8–12 weeks by computed tomography or magnetic resonance imaging.

Results

The overall response rate was 67 and 20 % of the patients had a complete response. The median times to local and systemic progression were respectively 10 and 14 months. The prognostic factors for time to local recurrence were response and number of tumors. The median survival time was 22 months. The prognostic factors for survival were response, largest tumor diameter, and number of tumors. Five patients (7 %) died within 30 days, and six patients (9 %) experienced major complications (Clavien–Dindo 3/4).

Conclusions

Isolated hepatic perfusion is a treatment option with high response rates and tolerable mortality and morbidity. Whether IHP has a survival benefit compared with other treatment options currently is being investigated in a randomized trial.

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Acknowledgments

This study was supported by grants from the Signe and Olof Wallenius Foundation, The Göteborg Medical Society, Assar Gabrielsson Foundation, and the Wilhelm and Marina Lundgren’s Foundation.

Conflict of interest

There are no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Ilan Ben-Shabat, Valerio Belgrano & Roger Olofsson Bagge MD, PhD

  2. Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Lars Ny MD, PhD

  3. Sahlgrenska Cancer Center, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Jonas Nilsson PhD

  4. Transplant Institute, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Per Lindnér MD, PhD

Authors
  1. Ilan Ben-Shabat
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  2. Valerio Belgrano
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  3. Lars Ny MD, PhD
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  4. Jonas Nilsson PhD
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  5. Per Lindnér MD, PhD
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  6. Roger Olofsson Bagge MD, PhD
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Corresponding author

Correspondence to Roger Olofsson Bagge MD, PhD.

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Ben-Shabat, I., Belgrano, V., Ny, L. et al. Long-Term Follow-Up Evaluation of 68 Patients with Uveal Melanoma Liver Metastases Treated with Isolated Hepatic Perfusion. Ann Surg Oncol 23, 1327–1334 (2016). https://doi.org/10.1245/s10434-015-4982-5

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  • DOI: https://doi.org/10.1245/s10434-015-4982-5

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