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Lymph Node Involvement Pattern and Survival Differences of FIGO IIIC and FIGO IIIA1 Ovarian Cancer Patients After Primary Complete Tumor Debulking Surgery: A 10-Year Retrospective Analysis of the Tumor Bank Ovarian Cancer Network

Annals of Surgical Oncology volume 23, pages 1279–1286 (2016)Cite this article

Abstract

Objective

The main goal of the current study was to compare survival differences among subgroups of primary ovarian cancer patients in International Federation of Gynecology and Obstetrics (FIGO) stages IIIC and IIIA1 after complete tumor debulking surgery.

Methods

A total of 218 patients with primary ovarian cancer who received complete cytoreductive surgery were included in the current retrospective analysis of the validated Tumor Bank Ovarian Cancer Network Database, which covers the periods January 2002 until December 2012. According to their tumor spread pattern, patients were divided into three groups: Group A (peritoneum only), Group B (peritoneum and lymph nodes), and Group C (lymph nodes only). Associations between groups and clinicopathological factors were analyzed using standard statistical procedures.

Results

The vast majority of patients were classified into Group B. Lymph node involvement was detected in 70.5 % of the cases where peritoneal implants presented ≥2 cm beyond the pelvis (Group A + B). The estimated 5-year overall survival (OS) rates were 47.4 % in Group A, 45.1 % in Group B, and 91.7 % in Group C (p < 0.01). In the subgroup analysis of Group B, both pelvic and para-aortic lymph node involvement was found in 57 % of patients. Patients in Group B who had para-aortic lymph node involvement only had better median progression-free survival (PFS) compared with patients with pelvic lymph node involvement only and pelvic and para-aortic lymph node involvement (28, 16, and 18 months, respectively; p = 0.02). The median OS differed significantly between patients with para-aortic lymph node involvement only versus patients with both pelvic and para-aortic involvement (68.5 vs. 46.7 months; p = 0.02). Three-year PFS was 90.0 % in FIGO IIIA1(i) and 62.6 % in FIGO IIIA1(ii) (hazard ratio 2.30, 95 % confidence interval 0.45–11.58).

Conclusions

Patients with FIGO stage IIIC with lymph node involvement only had the best clinical outcome compared with patients in the same stage with peritoneal involvement only. Furthermore, involvement of both pelvic and para-aortic lymph nodes were of the same infrequency, and involvement of only para-aortic lymph nodes in this stage resulted in a better chance of survival than involvement of pelvic lymph nodes only or both pelvic and para-aortic lymph nodes simultaneously. In accordance with the revised FIGO classification of 2013, our study revealed that FIGO IIIA1(i) is prognostically better compared with FIGO IIIA1(ii).

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Acknowledgment

This Project was supported by a research Grant from Berliner Krebsgesellschaft e.V.

Author information

Affiliations

  1. Department of Gynecology, Virchow Campus Clinic, Charité Medical University Berlin, Berlin, Germany

    Khayal Gasimli, Elena Ioana Braicu MD, Rolf Richter MPH, Radoslav Chekerov MD, Jalid Sehouli MD, PhD & Mustafa Zelal Muallem MD

  2. Tumor Bank Ovarian Cancer Network (TOC), European Competence Center for Ovarian Cancer, Charité Comprehensive Cancer Center (CCCC), Berlin, Germany

    Khayal Gasimli, Elena Ioana Braicu MD, Mani Nassir, Rolf Richter MPH, Aygun Babayeva, Radoslav Chekerov MD & Jalid Sehouli MD, PhD

  3. Institute of Pathology, Virchow Campus Clinic, Charité Medical University Berlin, Berlin, Germany

    Silvia Darb-Esfahani MD, PhD

Authors
  1. Khayal Gasimli
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  2. Elena Ioana Braicu MD
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  3. Mani Nassir
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  6. Radoslav Chekerov MD
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  8. Jalid Sehouli MD, PhD
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  9. Mustafa Zelal Muallem MD
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Corresponding author

Correspondence to Jalid Sehouli MD, PhD.

Additional information

FIGO IIIC: according to the FIGO classification of 1985.

FIGO IIIA1: according to the revised FIGO classification of 2013.

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Gasimli, K., Braicu, E.I., Nassir, M. et al. Lymph Node Involvement Pattern and Survival Differences of FIGO IIIC and FIGO IIIA1 Ovarian Cancer Patients After Primary Complete Tumor Debulking Surgery: A 10-Year Retrospective Analysis of the Tumor Bank Ovarian Cancer Network. Ann Surg Oncol 23, 1279–1286 (2016). https://doi.org/10.1245/s10434-015-4959-4

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Keywords

  • Overall Survival
  • Ovarian Cancer
  • Epithelial Ovarian Cancer
  • Ovarian Cancer Patient
  • Pelvic Lymph Node