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Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020)

Annals of Surgical Oncology volume 23, pages 722–728 (2016)Cite this article

Abstract

Background

Lobular neoplasia (LN) represents a spectrum of atypical proliferative lesions, including atypical lobular hyperplasia and lobular carcinoma-in-situ. The need for excision for LN found on core biopsy (CB) is controversial. We conducted a prospective multi-institutional trial (TBCRC 20) to determine the rate of upgrade to cancer after excision for pure LN on CB.

Methods

Patients with a CB diagnosis of pure LN were prospectively identified and consented to excision. Cases with discordant imaging and those with additional lesions requiring excision were excluded. Upgrade rates to cancer were quantified on the basis of local and central pathology review. Confidence intervals and sample size were based on exact binomial calculations.

Results

A total of 77 of 79 registered patients underwent excision (median age 51 years, range 27–82 years). Two cases (3 %; 95 % confidence interval 0.3–9) were upgraded to cancer (one tubular carcinoma, one ductal carcinoma-in-situ) at excision per local pathology. Central pathology review of 76 cases confirmed pure LN in the CB in all but two cases. In one case, the tubular carcinoma identified at excision was also found in the CB specimen, and in the other, LN was not identified, yielding an upgrade rate of one case (1 %; 95 % CI 0.01–7) by central pathology review.

Conclusions

In this prospective study of 77 patients with pure LN on CB, the upgrade rate was 3 % by local pathology and 1 % by central pathology review, demonstrating that routine excision is not indicated for patients with pure LN on CB and concordant imaging findings.

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Acknowledgment

We are grateful for the funding support to the TBCRC from the AVON Foundation, the Breast Cancer Research Foundation, and Susan G. Komen.

Disclosure

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Dana-Farber/Harvard Cancer Center, Boston, MA, USA

    Faina Nakhlis MD, Rebecca Gelman PhD, J. Dirk Iglehart MD, Elizabeth Lawler BA, Nicole Y. Ryabin BS & Mehra Golshan MD

  2. Mount Auburn Hospital, Cambridge, MA, USA

    Lauren Gilmore MD

  3. Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Clifford Hudis MD

  4. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Isabelle Bedrosian MD

  5. Indiana University Cancer Center, Indianapolis, IN, USA

    Kandice Ludwig MD

  6. Duke University Medical Center, Durham, NC, USA

    E. Shelley Hwang MD

  7. Georgetown University Cancer Center, Washington, DC, USA

    Shawna Willey MD

  8. Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA, USA

    Faina Nakhlis MD, J. Dirk Iglehart MD & Mehra Golshan MD

  9. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Stuart J. Schnitt MD

  10. Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Tari A. King MD

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  1. Faina Nakhlis MD
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  2. Lauren Gilmore MD
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  3. Rebecca Gelman PhD
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  4. Isabelle Bedrosian MD
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  5. Kandice Ludwig MD
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  6. E. Shelley Hwang MD
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  7. Shawna Willey MD
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  8. Clifford Hudis MD
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  9. J. Dirk Iglehart MD
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  10. Elizabeth Lawler BA
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  13. Stuart J. Schnitt MD
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  14. Tari A. King MD
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Corresponding author

Correspondence to Tari A. King MD.

Additional information

Dr. Stuart J. Schnitt and Dr. Tari A. King share senior authorship of this article.

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Nakhlis, F., Gilmore, L., Gelman, R. et al. Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). Ann Surg Oncol 23, 722–728 (2016). https://doi.org/10.1245/s10434-015-4922-4

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Keywords

  • Core Biopsy
  • Tubular Carcinoma
  • Lobular Neoplasia
  • Central Pathology Review
  • Atypical Lobular Hyperplasia