Annals of Surgical Oncology

, Volume 22, Supplement 3, pp 699–706 | Cite as

Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing’s Syndrome

  • Vladimir NeychevEmail author
  • Seth M. Steinberg
  • Lily Yang
  • Amit Mehta
  • Naris Nilubol
  • Margaret F. Keil
  • Lynnette Nieman
  • Constantine A. Stratakis
  • Electron Kebebew
Endocrine Tumors



Laparoscopic bilateral adrenalectomy (LBA) is recommended for patients with bilateral adrenal disease and occult or unresectable ectopic Cushing’s syndrome (CS). There are limited data on long-term outcomes after LBA, partly due to the lack of disease-specific tools for the measurement of impact on patients’ health and quality of life.


We used a disease-specific questionnaire covering all major clinicopathologic characteristics of CS. We compared the outcome from LBA to a control group of 60 patients who had thyroidectomy (matched for age, gender, and time of surgery, 2:1 control-to-CS).


Twenty-eight patients (20 women and 8 men) underwent LBA for CS. Of them, 24 patients (86 %) provided responses to our questionnaire. Ninety-two percent of patients’ responses indicated a significant improvement of general Cushing’s physical features with complete resolution reported in 59 % of responses. Significant improvement of associated biochemical abnormalities and comorbidities was reported in 83 % of patients’ responses including complete reversal in 58 %. Significant improvement in emotional-behavioral symptoms was reported in 84 % of patients’ responses with complete recovery in 53 %. All patients expressed satisfaction with LBA and significant improvement in their general health and self-reported quality of life. All of the improvements after LBA were statistically significant compared with the control group.


Our disease-specific questionnaire enables a clearer understanding of the association between the clinical, metabolic, and emotional-behavioral features of CS, its treatment with LBA, and long-term impact on patient-reported quality of life. This disease-specific questionnaire may be useful for future studies in patients with CS.


Primary Pigment Nodular Adrenocortical Disease Adrenal Rest Hydrocortisone Sodium Succinate Malignant Thyroid Disease Steroid Replacement Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The study was supported by the NIH clinical protocols NCT00005927, NCT01005654, and NCT02001051.

Conflict of interest

Authors have no conflict of interest to declare.

Supplementary material

10434_2015_4605_MOESM1_ESM.doc (62 kb)
Supplementary material 1 (DOC 61 kb)
10434_2015_4605_MOESM2_ESM.doc (66 kb)
Supplementary material 2 (DOC 66 kb)
10434_2015_4605_MOESM3_ESM.pdf (242 kb)
Supplementary material 3 (PDF 241 kb)


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Copyright information

© Society of Surgical Oncology 2015

Authors and Affiliations

  • Vladimir Neychev
    • 1
    Email author
  • Seth M. Steinberg
    • 2
  • Lily Yang
    • 1
  • Amit Mehta
    • 1
  • Naris Nilubol
    • 1
  • Margaret F. Keil
    • 3
  • Lynnette Nieman
    • 4
  • Constantine A. Stratakis
    • 3
  • Electron Kebebew
    • 1
  1. 1.Endocrine Oncology Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Biostatistics and Data Management Section, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA
  4. 4.Section on Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA

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