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Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands

  • Head and Neck Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The clinical behavior and treatment outcomes of salivary gland myoepithelial carcinoma have yet to be clearly defined. The current study investigated risk factors and prognoses for this tumor.

Methods

A retrospective review of the medical records for 32 patients with myoepithelial carcinoma of the major salivary glands was performed. Their clinical parameters were assessed to identify correlations with local-regional recurrence, distant metastasis, and survival.

Results

The 5-year survival rate was 71 %. Of the reviewed patients, 41 % had local-regional recurrences, and 22 % had distant metastases. Age of 60 years or younger was a predictive factor for distant metastasis. Patients with neck lymph nodes clinically positive for carcinoma had shorter overall survival durations than those with nodes negative for carcinoma.

Conclusions

Myoepithelial carcinoma of the major salivary glands is characterized by a high incidence of local-regional recurrence and distant metastasis. Adjuvant therapy is indicated for selected patients with high-risk disease.

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Conflict of interest

The authors made no disclosures and listed no grant support.

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Authors and Affiliations

  1. Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, People’s Republic of China

    Yu-xiong Su MD, DDS

  2. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Yu-xiong Su MD, DDS, Dianna B. Roberts PhD, Ehab Y. Hanna MD, Randal S. Weber MD & Michael E. Kupferman MD

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Adel El-Naggar MD, PhD

  4. Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

    Güleser Saylam MD

  5. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Steven J. Frank MD

Authors
  1. Yu-xiong Su MD, DDS
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  2. Dianna B. Roberts PhD
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  3. Ehab Y. Hanna MD
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  4. Adel El-Naggar MD, PhD
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  5. Güleser Saylam MD
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  6. Steven J. Frank MD
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  7. Randal S. Weber MD
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  8. Michael E. Kupferman MD
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Corresponding author

Correspondence to Michael E. Kupferman MD.

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Su, Yx., Roberts, D.B., Hanna, E.Y. et al. Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands. Ann Surg Oncol 22, 3701–3707 (2015). https://doi.org/10.1245/s10434-015-4389-3

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  • DOI: https://doi.org/10.1245/s10434-015-4389-3

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