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Does Completion Thyroidectomy Improve the Outcome of Patients with Minimally Invasive Follicular Carcinoma of the Thyroid?

  • Endocrine Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The diagnosis of minimally invasive follicular thyroid carcinoma (MIFTC) is often made histologically after thyroid lobectomy. We attempted to determine whether completion thyroidectomy should be considered necessary for all patients diagnosed with MIFTC after thyroid lobectomy.

Methods

The subjects of this study were a total of 324 patients who underwent thyroid lobectomy as initial surgery at our institution between 1989 and 2010 and diagnosed histologically as MIFTC. Completion thyroidectomy was performed on 101 patients, and the other 223 patients were followed up without further treatments. Cumulative cause-specific survival (CSS) rates and distant-metastasis-free survival (DMFS) rates were calculated by the Kaplan–Meier method. Differences between groups were analyzed for statistical significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazards model.

Results

During the follow-up period, 39 patients were diagnosed with distant metastasis, and 7 patients died of their disease. Age at the initial surgery was found to be a significant factor related to DMFS in both the univariate and multivariate analysis and to also be related to CSS in the univariate analysis. Completion thyroidectomy did not have a significant effect on DMFS or CSS according to the results of the univariate analysis, but it had significant effect on DMFS according to the results of the multivariate analysis.

Conclusions

Although we were unable to demonstrate sufficient statistical evidence that completion thyroidectomy improved the outcome of MIFTC patients, it is noteworthy none of the patient who underwent completion thyroidectomy died of the disease.

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Conflict of interest

The authors declare that no competing financial interests exist.

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Authors and Affiliations

  1. Department of Surgery, Ito Hospital, Tokyo, Japan

    Kiminori Sugino MD, Mitsuji Nagahama MD, Wataru Kitagawa MD, Hiroshi Shibuya MD, Keiko Ohkuwa MD, Takashi Uruno MD, Junko Akaishi MD, Akifumi Suzuki MD, Chie Masaki MD, Ken-ichi Matsuzu MD, Michikazu Kawano MD & Koichi Ito MD

  2. Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan

    Kaori Kameyama MD

Authors
  1. Kiminori Sugino MD
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  2. Kaori Kameyama MD
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  3. Mitsuji Nagahama MD
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  4. Wataru Kitagawa MD
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  5. Hiroshi Shibuya MD
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  6. Keiko Ohkuwa MD
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  7. Takashi Uruno MD
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  8. Junko Akaishi MD
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  9. Akifumi Suzuki MD
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  10. Chie Masaki MD
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  11. Ken-ichi Matsuzu MD
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  12. Michikazu Kawano MD
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  13. Koichi Ito MD
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Correspondence to Kiminori Sugino MD.

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Sugino, K., Kameyama, K., Nagahama, M. et al. Does Completion Thyroidectomy Improve the Outcome of Patients with Minimally Invasive Follicular Carcinoma of the Thyroid?. Ann Surg Oncol 21, 2981–2986 (2014). https://doi.org/10.1245/s10434-014-3734-2

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  • DOI: https://doi.org/10.1245/s10434-014-3734-2

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