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Multicenter Study to Assess Endoscopic Resection of 159 Sinonasal Adenocarcinomas

  • Head and Neck Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

This study was designed to assess the efficacy and morbidity of the endoscopic endonasal approach for the treatment of sinonasal adenocarcinomas.

Methods

This was a retrospective, multicenter study of nine French tertiary referral centers, including untreated patients. All patients were operated by an endoscopic approach. Tumors were classified according to the UICC 2002. Demographic, therapeutic, histological, morbidity data, and the course of the disease were recorded. Survival rates were obtained using the Kaplan-Meier method.

Results

A total of 159 patients were included with a mean age of 69 years. There were 19T1, 62T2 (1M1), 36T3 (1N1), 26T4a, and 16T4b (1N2a-1N2c). The mean duration of hospitalization was 4.4 days. The histologic outcomes showed that the olfactory cleft, the posterior and anterior ethmoid sinus, and the sphenoid, maxillary, and frontal sinuses were invaded in 95, 64, 55, 19, 7, and 3 % of cases, respectively. Histologic margins were positive in 17 % (1T1, 4T2, 3T3, 2T4a, and 8T4b). In total, 130 patients received adjuvant radiotherapy on the primary tumor site (58 Gy), 24 cases were not irradiated, and 5 refused treatment. The mean follow-up was 32.5 ± 24 months. The complication rate was 19 %: 6 epistaxis, 3 meningitis, 6 CSF leaks, 2 dacryocystitis, and 8 septoplasties. The recurrence rate was 17.6 % (28 cases) within 23 ± 21 months. Eleven patients underwent a second surgical procedure. Nine patients died of their disease (3T2, 2T3, 4T4b). The global and disease-specific, recurrence-free survival rate at 3 years was 74 and 84 % respectively.

Conclusions

The endoscopic approach seems to be efficient to remove sinonasal adenocarcinoma with low morbidity.

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Acknowledgment

The authors thank Dr. Ray Cooke for linguistic assistance and Dr Antoine Benard for statistic analysis.

Financial support and conflict of interest

The authors have received no financial support and have no conflict of interest.

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Authors and Affiliations

  1. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Rangueil-Larrey, Toulouse, France

    Sebastien Vergez MD, PhD & Elie Serrano MD, MSc

  2. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Creteil, Creteil, France

    Marie Devars du Mayne MD & Andre Coste MD, PhD

  3. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Nancy, Nancy, France

    Patrice Gallet MD & Roger Jankowski MD, PhD

  4. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Bernard, Poitiers, France

    Xavier Dufour MD, PhD

  5. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Grenoble, Grenoble, France

    Christian Righini MD, PhD & Emile Reyt MD

  6. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Charles Nicolle, Rouen, France

    Olivier Choussy MD

  7. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Gui de Chauliac, Montpellier, France

    Louis Crampette MD, PhD

  8. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital de Hautepierre, Strasbourg, France

    Christian Debry MD, PhD

  9. Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Bordeaux, F-X Michelet Center, Bordeaux cedex, France

    Ludovic de Gabory MD, PhD

Authors
  1. Sebastien Vergez MD, PhD
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  2. Marie Devars du Mayne MD
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  3. Andre Coste MD, PhD
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  4. Patrice Gallet MD
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  5. Roger Jankowski MD, PhD
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  6. Xavier Dufour MD, PhD
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  7. Christian Righini MD, PhD
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  8. Emile Reyt MD
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  9. Olivier Choussy MD
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  10. Elie Serrano MD, MSc
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  11. Louis Crampette MD, PhD
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  12. Christian Debry MD, PhD
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  13. Ludovic de Gabory MD, PhD
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Corresponding author

Correspondence to Ludovic de Gabory MD, PhD.

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Vergez, S., du Mayne, M.D., Coste, A. et al. Multicenter Study to Assess Endoscopic Resection of 159 Sinonasal Adenocarcinomas. Ann Surg Oncol 21, 1384–1390 (2014). https://doi.org/10.1245/s10434-013-3385-8

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  • DOI: https://doi.org/10.1245/s10434-013-3385-8

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