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Oncologic Safety of Pylorus-preserving Gastrectomy in the Aspect of Micrometastasis in Lymph Nodes at Stations 5 and 6

Annals of Surgical Oncology volume 21, pages 533–538 (2014)Cite this article

Abstract

Background

Pylorus-preserving gastrectomy (PPG) is a function-preserving gastrectomy for early gastric cancers (EGCs) that are preoperatively assessed as pN0 tumors and located in the middle portion of the stomach. In PPG, dissection of the lymph nodes at stations 5 and 6 is frequently incomplete, and this may be worrisome in terms of oncologic safety.

Methods

We examined lymph nodes collected from stations 5 and 6 from 196 patients who had undergone conventional distal gastrectomy (CDG) for EGC located in the middle portion of the stomach and from 24 patients who had undergone PPG.

Results

The average number of lymph nodes collected at station 5 was significantly lower with PPG than with CDG (0.08 vs. 1.32, respectively; P = 0.008). However, such a difference was not noted for station 6 nodes. The rate of macrometastasis was very low in all station 5 nodes (1 of 220, 0.45 %) and station 6 nodes (1 of 220, 0.45 %). Immunohistochemical analysis of cytokeratin in 109 cases of the CDG group and 21 cases of the PPG group showed that micrometastasis of single isolated tumor cell type was observed in only one station 6 lymph node of a patient who was initially diagnosed with pN0 EGC. There were no cases of micrometastasis in station 5 nodes.

Conclusions

The possibility of micrometastasis to station 5 and/or 6 lymph nodes may be negligible for EGC located in the middle portion of the stomach, and PPG thus might be the oncologically safe procedure when considering micrometastasis in remaining nodes in vivo at stations 5 and 6.

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Acknowledgment

This study was supported by a faculty research grant of Yonsei University College of Medicine for 2010 (6-2010-0109).

Disclosure

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea

    Baek-hui Kim MD, PhD

  2. Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

    Soon Won Hong MD, PhD & Sun Och Yoon MD, PhD

  3. Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

    Jong Won Kim MD, PhD & Seung Ho Choi MD, PhD

Authors
  1. Baek-hui Kim MD, PhD
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  2. Soon Won Hong MD, PhD
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  3. Jong Won Kim MD, PhD
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  4. Seung Ho Choi MD, PhD
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  5. Sun Och Yoon MD, PhD
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Correspondence to Sun Och Yoon MD, PhD.

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Kim, Bh., Hong, S.W., Kim, J.W. et al. Oncologic Safety of Pylorus-preserving Gastrectomy in the Aspect of Micrometastasis in Lymph Nodes at Stations 5 and 6. Ann Surg Oncol 21, 533–538 (2014). https://doi.org/10.1245/s10434-013-3252-7

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  • DOI: https://doi.org/10.1245/s10434-013-3252-7

Keywords

  • Lymph Node
  • Early Gastric Cancer
  • Metastatic Lymph Node
  • Middle Portion
  • Isolate Tumor Cell