Abstract
Background
Health-related quality of life (HRQL) is an important outcome measurement in oncology. Our aim was to validate the Mexican Spanish version of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-H&N35 questionnaire to measure HRQL in patients with head and neck cancers.
Methods
The QLQ-C30 and QLQ-H&N35 instruments were applied to Mexican patients with head and neck cancer at a cancer referral center. Reliability and validity tests were performed. Test–retest was carried out in selected patients.
Results
One hundred ninety-three patients were included in this cohort; tumor locations included the following: oral cavity 45 (23.3 %); larynx 35 (18.1 %); thyroid carcinoma invasive to aerodigestive tract 32 (16.6 %); oropharynx 17 (8.8 %); hypopharynx 12 (6.2 %); nasal cavity and paranasal sinuses 11 (5.7 %); salivary glands 11 (5.7 %); nasopharynx 8 (4.1 %); eye and adnexa 7 (3.6 %); cervical metastases of unknown origin 5 (2.6 %); primary sarcoma of the head and neck region 5 (2.6 %); maxillary antrum carcinoma 4 (2.1 %); and retinoblastoma 1 (0.5 %). Questionnaire compliance rates were high, and the instrument was well accepted; the internal consistency tests demonstrated good convergent and divergent validity. Cronbach’s α coefficients of 8 of 9 multi-item scales of the QLQ-C30 and 6 of 8 scales of the QLQ-H&N35 instruments were >0.7 (range 0.22–0.89). Scales of the QLQ-C30 and QLQ-H&N35 instruments distinguished among clinically distinct groups of patients; some were highly sensitive to change over time.
Conclusions
The Mexican Spanish version of the QLQ-H&N35 questionnaire is reliable and valid for the assessment of HRQL in patients with head and neck cancers and can be used in clinical trials in Mexican communities.
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References
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008: Cancer incidence and mortality worldwide. IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer; 2010. http://globocan.iarc.fr.
Verdonck-de Leeuw IM, van Nieuwenhuizen A, Leemans CR. The value of quality-of-life questionnaires in head and neck cancer. Curr Opin Otolaryngol Head Neck Surg. 2012;20:142–7.
Brizel DM, Lydiatt W, Colevas AD. Controversies in the locoregional management of head and neck cancer. J Natl Compr Canc Netw. 2011;9:653–62.
Tschudi D, Stoeckli S, Schmid S. Quality of life after different treatment modalities for carcinoma of the oropharynx. Laryngoscope. 2003;113:1949–54.
Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.
Bjordal K, Ahlner-Elmqvist M, Tollesson E, et al. Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients: EORTC Quality of Life Study Group. Acta Oncol. 1994;33:879–85.
Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire–H&N35. J Clin Oncol. 1999;17:1008–19.
Bjordal K, de Graeff A, Fayers PM, et al. A 12-country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC Quality of Life Group. Eur J Cancer. 2000;36:1796–807.
Jensen K, Jensen AB, Grau C. A cross sectional quality of life study of 116 recurrence free head and neck cancer patients. The first use of EORTC H&N35 in Danish. Acta Oncol. 2006;45:28–37.
Yang Z, Meng Q, Luo J, et al. Development and validation of the simplified Chinese version of EORTC QLQ-H&N35 for patients with head and neck cancer. Support Care Cancer. 2012;20:1555–64.
Chie WC, Hong RL, Lai CC, Ting LL, Hsu MM. Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35. Qual Life Res. 2003;12:93–8.
Tschiesner U, Rogers SN, Harréus U, Berghaus A, Cieza A. Content comparison of quality of life questionnaires used in head and neck cancer based on the International Classification of Functioning, Disability and Health: a systematic review. Eur Arch Otorhinolaryngol. 2008;265:627–37.
Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A; American Joint Committee on Cancer. AJCC cancer staging manual. 7th edition. New York: Springer; 2010.
Oñate-Ocaña LF, Alcántara-Pilar A, Vilar-Compte D, et al. Validation of the Mexican Spanish version of the EORTC C30 and STO22 questionnaires for the evaluation of health-related quality of life in patients with gastric cancer. Ann Surg Oncol. 2009;16:88–95.
Koller M, Aaronson NK, Blazeby JM, et al. Translation procedures for standardized quality of life questionnaires: The European Organization for Research and Treatment of Cancer (EORTC) approach. Eur J Cancer. 2007;43:1810–20.
Fayers PM, Aaronson NK, Bjordal K, et al. The EORTC QLQ-C30 scoring manual. 3rd edition. Brussels, Belgium: European Organisation for Research and Treatment of Cancer; 2001.
Tabachnik BJ, Fidell LS. Using multivariate statistics. London: Harper & Row; 1993.
Fayers PM, Machin D. Quality of life: assessment, analysis and interpretation. 2nd edition. London: Wiley; 2007.
Nalbadian M, Nikolaidis V, Nikolaou A, Themelis C, Kouloulas A, Vital V. Psychometric properties of the EORTC head and neck—specific quality of life questionnaire in disease-free Greek patients with cancer of pharynx and larynx. Qual Life Res. 2010;19:761–8.
Bower WF, Vlantis AC, Chung TM, Cheung SK, Bjordal K, van Hasselt CA. Quality of life in head and neck cancer patients after surgical resection: translation into Cantonese and validation of the EORTC QLQ-H&N35. Acta Otolaryngol. 2009;129:779–85.
Sherman AC, Simonton S, Adams DC, Vural E, Owens B, Hanna E. Assessing quality of life in patients with head and neck cancer: cross-validation of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Head and Neck Module (QLQ-H&N35). Arch Otolaryngol Head Neck Surg. 2000;126:459–67.
McNair AG, Brookes ST, Davis CR, Argyropoulos M, Blazeby JM. Communicating the results of randomized clinical trials: do patients understand multidimensional patient-reported outcomes? J Clin Oncol. 2010;28:738–43.
Quinten C, Coens C, Mauer M, et al. Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncol. 2009;10:865–71.
Nibu K, Ebihara Y, Ebihara M, et al. Quality of life after neck dissection: a multicenter longitudinal study by the Japanese Clinical Study Group on standardization of treatment for lymph node metastasis of head and neck cancer. Int J Clin Oncol. 2010;15:33–8.
Acknowledgments
We thank the European Organisation for Research and Treatment of Cancer Quality of Life Group, particularly Linda Dewolf, for their extensive support in the translation procedures of the QLQ-H&N35 questionnaires. We thank Maggie Brunner, MA, for English-language editorial review.
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Carrillo, J.F., Ortiz-Toledo, M.Á., Salido-Noriega, Z. et al. Validation of the Mexican Spanish Version of the EORTC QLQ-H&N35 Instrument to Measure Health-related Quality of Life in Patients with Head and Neck Cancers. Ann Surg Oncol 20, 1417–1426 (2013). https://doi.org/10.1245/s10434-012-2712-9
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DOI: https://doi.org/10.1245/s10434-012-2712-9