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Characteristic Immunophenotype of Solid Subtype Component in Lung Adenocarcinoma

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Lung adenocarcinomas represent a morphologically heterogeneous tumor composed of an admixture of different histologic subtypes (lepidic, papillary, acinar, and solid subtype). The presence of a solid subtype component is reported to be associated with a poorer prognosis. The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components.

Methods

We analyzed the clinicopathological characteristics of stage I adenocarcinoma patients with predominant solid subtype disease. Furthermore, we immunostained adenocarcinomas with predominant lepidic, papillary, acinar, and solid subtype components (n = 23 each) for 10 molecular markers of tumor invasiveness and scored the results.

Results

Patients showing predominance of the solid subtype component (solid subtype adenocarcinoma) had a poorer prognosis than those showing predominance of the lepidic, papillary, or acinar component. Lymphovascular invasion was more often detected in solid subtype tumors than in others. The solid subtype component showed a significantly stronger staining intensity of laminin-5 expression than the lepidic, papillary, and acinar components (P < 0.001, P < 0.001, and P = 0.016, respectively). The fibronectin and vimentin expression levels were also significantly higher in the solid subtype component than in other components. This immunostaining character was validated by using mixed-subtype adenocarcinomas containing all four components in the same tumor.

Conclusions

This study concluded that the solid subtype component in lung adenocarcinomas exhibit the invasive immunophenotype, including increased laminin-5 expression, compared with the other components, which may be associated with a poorer prognosis.

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Authors and Affiliations

  1. Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

    Teruhisa Takuwa MD, Genichiro Ishii MD, PhD, Shinya Neri MD & Atsushi Ochiai MD, PhD

  2. Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

    Teruhisa Takuwa MD, Kanji Nagai MD, PhD, Junji Yoshida MD, PhD, Mitsuyo Nishimura MD, PhD, Tomoyuki Hishida MD, PhD & Shinya Neri MD

  3. Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    Teruhisa Takuwa MD & Seiki Hasegawa MD, PhD

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  1. Teruhisa Takuwa MD
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  2. Genichiro Ishii MD, PhD
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  3. Kanji Nagai MD, PhD
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  4. Junji Yoshida MD, PhD
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  8. Seiki Hasegawa MD, PhD
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  9. Atsushi Ochiai MD, PhD
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Correspondence to Genichiro Ishii MD, PhD or Atsushi Ochiai MD, PhD.

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Takuwa, T., Ishii, G., Nagai, K. et al. Characteristic Immunophenotype of Solid Subtype Component in Lung Adenocarcinoma. Ann Surg Oncol 19, 3943–3952 (2012). https://doi.org/10.1245/s10434-012-2428-x

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  • DOI: https://doi.org/10.1245/s10434-012-2428-x

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