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Childbearing After Hyperthermic Intraperitoneal Chemotherapy: Results From an International Survey

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) can improve survival in selected patients with primary or secondary peritoneal malignancies. With the opportunity for long-term survival, questions about the impact of those procedures in fertility in women of childbearing age can be raised.

Materials and Methods

An international survey was performed among all teams participating in the International Peritoneal Surface Malignancy Group in order to collect data about pregnancies and their outcome in women having undergone previous CRS with adjuvant HIPEC.

Results

There were 7 pregnancies reported after CRS and HIPEC in women treated for peritoneal malignancies. All these women conceived spontaneously, most of them within 2 years after the procedure. They delivered most often by vaginal way after an uneventful pregnancy. Their newborns were healthy, except 1 case of congenital diaphragmatic hernia requiring emergent surgery. There were 2 additional uneventful pregnancies reported after the diagnosis of pseudomyxoma peritonei and before CRS and HIPEC, with the support of the medical team. Another woman having undergone oocytes retrieval and embryo cryopreservation prior to the surgery was mother of twins after the procedure via a surrogate mother.

Conclusion

Childbearing after cytoreductive surgery and heated intraperitoneal chemotherapy is possible in women conserving their genital organs after the procedure. The question of fertility should be considered and discussed in women in reproductive age prior to cytoreductive surgery and heated intraperitoneal chemotherapy. Different options could be offered in this setting. Multidisciplinary decision making involving surgical oncologists and fertility specialists is important.

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Acknowledgment

This work was supported by a grant from the University Hospital of Dijon and the Regional Council of Burgundy 2009. This grant financed sending the questionnaire and the administrative costs of submission for ethics and for the national regulatory organism regarding confidentiality of data in medical research. The authors thank Peggy Jourdan-Enfer (Clinic Research Unit, Lyon) for collecting data and mailing the questionnaires and Agnès Maurer (Clinic Research Unit, Dijon) for her help with administrative formalities and CNIL and CCTIRS submission.

Conflict of interest

No other commercial sponsorship or conflict of interest are declared.

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Authors and Affiliations

  1. INSERM UMR 866, Dijon, France

    Pablo Ortega-Deballon MD, PhD & Patrick Rat MD

  2. University Hospital of Dijon, Dijon, France

    Pablo Ortega-Deballon MD, PhD, Audrey Facy MD & Patrick Rat MD

  3. University Hospital of Lyon South, Pierre Bénite, France

    Olivier Glehen MD, PhD & Naoual Bakrin MD

  4. Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA

    Edward Levine MD

  5. University Medical Center of Regensburg, Regensburg, Germany

    Pompiliu Piso MD

  6. Washington Cancer Institute, Columbia, Washington, DC, USA

    Paul H. Sugarbaker MD

  7. MD Anderson Cancer Center, Houston, TX, USA

    Andrea Hayes-Jordan MD

Authors
  1. Pablo Ortega-Deballon MD, PhD
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  2. Olivier Glehen MD, PhD
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  3. Edward Levine MD
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  4. Pompiliu Piso MD
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  5. Paul H. Sugarbaker MD
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  6. Andrea Hayes-Jordan MD
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  7. Audrey Facy MD
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  8. Naoual Bakrin MD
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  9. Patrick Rat MD
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Corresponding author

Correspondence to Pablo Ortega-Deballon MD, PhD.

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Ortega-Deballon, P., Glehen, O., Levine, E. et al. Childbearing After Hyperthermic Intraperitoneal Chemotherapy: Results From an International Survey. Ann Surg Oncol 18, 2297–2301 (2011). https://doi.org/10.1245/s10434-011-1595-5

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  • DOI: https://doi.org/10.1245/s10434-011-1595-5

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