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Impact of Postoperative Morbidity on Long-Term Survival After Resection for Colorectal Liver Metastases

Annals of Surgical Oncology volume 23, pages 929–937 (2016)Cite this article

Abstract

Background

Although correlation of postoperative morbidity with long-term survival is recognized to influence long-term survival after other cancer surgery, little information exists about the impact of postoperative morbidity on patient outcomes following liver resection for colorectal metastases.

Methods

We studied the impact of postoperative morbidity on long-term survival after liver resection for colorectal cancer metastases using data from 312 patients with curative hepatectomy.

Results

Among all 312 patients evaluated, 98 complications occurred, affecting 80 patients (26%). The 80 patients with morbidity had a lower disease-free rate (P = 0.03), resulting in poor overall survival (P = 0.02) compared with the group with no morbidity (n = 232). Decreases in disease-free and overall survival also were associated with severity of postoperative complications. When patients were divided according to extent of metastases, little impact of morbidity on overall survival (P = 0.10) and disease-free rate (P = 0.35) was demonstrated in patients whose metastases were less advanced. However, a negative impact of morbidity compared with no morbidity on disease-free rate (P < 0.01) and overall survival (P < 0.01) was confirmed in patients with aggressive or advanced metastases.

Conclusions

Postoperative morbidity had a negative impact on long-term survival, especially for aggressive or advanced metastases or severe complications.

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Affiliations

  1. Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Kuniya Tanaka MD, Takafumi Kumamoto MD, Kazunori Nojiri MD, Ryusei Matsuyama MD, Kazuhisa Takeda MD & Itaru Endo MD

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  1. Kuniya Tanaka MD
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  2. Takafumi Kumamoto MD
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  3. Kazunori Nojiri MD
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  4. Ryusei Matsuyama MD
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  5. Kazuhisa Takeda MD
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  6. Itaru Endo MD
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Correspondence to Kuniya Tanaka MD.

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Tanaka, K., Kumamoto, T., Nojiri, K. et al. Impact of Postoperative Morbidity on Long-Term Survival After Resection for Colorectal Liver Metastases. Ann Surg Oncol 23, 929–937 (2016). https://doi.org/10.1245/s10434-010-1352-1

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  • DOI: https://doi.org/10.1245/s10434-010-1352-1

Keywords

  • Postoperative Complication
  • Liver Resection
  • CDDP
  • Postoperative Morbidity
  • Colorectal Liver Metastasis