Abstract
Background
The role of surgery has changed substantially over the years in abdominal Burkitt’s lymphoma. Laparotomy without total excision of the tumor does not have a positive effect on survival, might cause complications, and delays initiation of chemotherapy. Here we present our diagnostic management of patients with abdominal Burkitt’s lymphoma.
Materials and Methods
The diagnostic methods of abdominal Burkitt’s lymphoma cases treated between January 1999 and December 2009 were evaluated retrospectively.
Results
Of the 48 abdominal Burkitt’s lymphoma patients, 13 also had extra-abdominal site involvement. Diagnosis was made with ultrasound-guided tru-cut needle biopsy of the abdominal mass (n = 11), fluid cytology (n = 7), extra-abdominal site biopsy (n = 4), bone marrow aspiration (n = 2), gastroscopy (n = 1), and laparotomy (n = 23). In patients diagnosed with laparotomy, chemotherapy was started in 4–22 days (median 7) compared with patients diagnosed with other diagnostic interventions in 2–4 days (median 2) (P < .001).
Conclusion
Although the most frequently used technique is laparotomy and open biopsy in our series, other methods provided quicker initiation of chemotherapy and less surgical morbidity. Especially in patients with high stages, cytological evaluation and tru-cut needle biopsy with radiological guidance is a better alternative of laparotomy.
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References
Murphy SB, Fairclough DL, Hutchison RE, Berard CW. Non-Hodgkin’s lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. J Clin Oncol. 1989;7:186–93.
Link MP, Weinstein HJ. Malignant non-Hodgkin’s lymphoma in children. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 2nd ed. Philadelphia: J.B. Lippincott Company; 2006. p. 722–47.
Billmire DF. Lymphoma. In: Carachi R, Grosfeld JL, Azmy AF, editors. The surgery of childhood tumors. 2nd ed. Berlin Heidelberg: Springer-Verlag; 2008, p. 304–17.
Kaufman BH, Burgert EO, Banks PM. Abdominal Burkitt’s lymphoma: role of early aggressive surgery. J Pediatr Surg. 1987;22:671–74.
LaQuaglia MP, Stolar CJ, Krailo M, Exelby P, Siegel S, Meadows A, et al. The role of surgery in abdominal non-Hodgkin’s lymphoma: experience from the Childrens Cancer Study Group. J Pediatr Surg. 1992;27:230–5.
Attarbaschi A, Mann G, Dworzak M, Trebo M, Mühlegger N, Reiter A, et al. The role of surgery in the treatment of pediatric B-cell non-Hodgkin’s lymphoma. J Pediatr Surg. 2002;37:1470–5.
Delarue A, Bergeron C, Mechinaud-Lacroix F, Coze C, Raphael M, Patte C. Pediatric non-Hodgkin’s lymphoma: primary surgical management of patients presenting with abdominal symptoms. Recommendations of the Lymphoma Committee of the French Society to Combat Pediatric Cancers (SFCE). J Chir. 2008;145:454–8.
Gerrard M, Cairo MS, Weston C, Auperin A, Pinkerton R, Lambilliote A, et al. FAB LMB 96 International Study Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin’s lymphoma: results of the FAB/LMB 96 international study. Br J Haematol. 2008;141:840–7.
Gahukamble DB, Khamage AS. Limitations of surgery in intraabdominal Burkitt’s lymphoma in children. J Pediatr Surg. 1995;30:519–22.
Miron I, Frappaz D, Brunat-Mentigny M, Combaret V, Buclon M, Bouffet E, et al. Initial management of advanced Burkitt’s lymphoma in children: is there still a place for surgery? Pediatr Hematol Oncol. 1997;14:555–61.
Farley-Hills E, Byrne AJ, Brennan L, Sartori P. Tumour lysis syndrome during anaesthesia. Paediatr Anaesth. 2001;11:233–6.
Lee MH, Cheng KI, Jang RC, Hsu JH, Dai ZK, Wu JR. Tumour lysis syndrome developing during an operation. Anaesthesia. 2007;62:85–7.
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Vural, S., Baskin, D., Dogan, Ö. et al. Diagnosis in Childhood Abdominal Burkitt’s Lymphoma. Ann Surg Oncol 17, 2476–2479 (2010). https://doi.org/10.1245/s10434-010-1113-1
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DOI: https://doi.org/10.1245/s10434-010-1113-1