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A Clinicopathologic Analysis of Peritoneal Metastases of Colorectal and Appendiceal Origin

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Objective

To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.

Background

This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods

Histology of PM (n = 269) was evaluated by analysis of mitotic activity, atypia, cellularity, and mucinous component. For overall survival (OS) and disease-free survival (DFS) Cox proportional-hazard models were constructed. Covariates included tumor, patient, and treatment characteristics.

Results

PM could be categorized into four groups: low-grade, well-differentiated mucinous tumor (DPAM); intermediated-grade mucinous carcinoma (PMCA-i); high-grade mucinous carcinoma (PMCA); and high-grade nonmucinous carcinoma (PCA). Multivariate analysis showed that histological classification, gender, number of segments affected, completeness of cytoreduction, and HIPEC as primary treatment were significant related to OS and DFS. The 5-year OS was 64% in the DPAM group, 36% in the PMCA group, and 24% in the PCA group. Of PM originating from an appendix tumor, 29% were of non-DPAM type. Of primary colorectal tumors, 37% resulted in mucinous PM, and another 26% of PM of colorectal origin had partly mucinous histology.

Conclusion

Histology is a significant predictive factor of OS and DFS in PM treated with surgical cytoreduction and HIPEC. Low-grade PM (DPAM) should be regarded as a separate entity because of its clearly different clinical course. High-grade mucinous PM has significant better prognosis than nonmucinous PM and should thus be distinguished.

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Acknowledgment

We would like to thank Dr. Daphne de Jong and Dr. Henk Boot for their critical reading of the manuscript. We thank Dr. Frans Zoetmulder (FZ) for initiating this research project.

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Authors and Affiliations

  1. Division of Experimental Therapy, Department of Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Sjoerd C. Bruin MD

  2. Department of Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Victor J. Verwaal MD, PhD

  3. Department of Biostatistics, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Andrew Vincent MSc

  4. Division of Experimental Therapy, Department of Pathology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Laura J. van‘t Veer PhD

  5. Department of Pathology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Marie-Louise F. van Velthuysen MD, PhD

Authors
  1. Sjoerd C. Bruin MD
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  2. Victor J. Verwaal MD, PhD
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  3. Andrew Vincent MSc
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  4. Laura J. van‘t Veer PhD
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  5. Marie-Louise F. van Velthuysen MD, PhD
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Corresponding author

Correspondence to Marie-Louise F. van Velthuysen MD, PhD.

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Disclosure The authors have no conflict of interest to disclose.

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Bruin, S.C., Verwaal, V.J., Vincent, A. et al. A Clinicopathologic Analysis of Peritoneal Metastases of Colorectal and Appendiceal Origin. Ann Surg Oncol 17, 2330–2340 (2010). https://doi.org/10.1245/s10434-010-0984-5

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  • DOI: https://doi.org/10.1245/s10434-010-0984-5

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