Abstract
Background
Differences in psychological outcomes of breast cancer patients with locally advanced disease who presented with abnormal screening mammograms or palpable mass have not been reported.
Methods
We interviewed 120 women with clinical stage II/III breast cancer enrolled onto a prospective phase 2 clinical trial at diagnosis and 1 year after diagnosis, inquiring about demographics, depressive symptoms, social support, and perceived risk of disease recurrence. Presentation method (abnormal screening mammogram or symptoms) was determined by chart review. Change in depressed mood was assessed by repeated measures analysis of covariance, grouping by presentation method.
Results
A significant interaction was observed between presentation method and change in depressed mood among 86 women without disease progression who completed both interviews. Women presenting with breast symptoms experienced a decrease and women presenting with abnormal screening mammogram experienced an increase in depressed mood (P = 0.032).
Conclusions
Women diagnosed with locally advanced breast cancer by screening mammography showed increased depressed mood a year after diagnosis. Therefore, identification of locally advanced breast cancer by screening mammogram may be a risk factor for posttreatment depression.
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Acknowledgment
Funding for this study was provided in part by grants from Novartis, Pfizer, and a Predoctoral Interdisciplinary Clinical Research Training Program grant from the National Institute of Child Health and Human Development (T32 HD052266; PI: Jay Piccirillo, MD). We thank the women who participated in this study and the Health Behavior and Outreach Core of the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, Missouri, especially Maria Perez and Jennifer Tappenden, for data management services. The Health Behavior and Outreach Core is supported in part by a National Cancer Institute Cancer Center support grant (P30 CA91842) to the Siteman Cancer Center.
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Roth, E.B., Jeffe, D.B., Margenthaler, J.A. et al. Method of Breast Cancer Presentation and Depressed Mood 1 Year After Diagnosis in Women with Locally Advanced Disease. Ann Surg Oncol 16, 1637–1641 (2009). https://doi.org/10.1245/s10434-009-0445-1
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DOI: https://doi.org/10.1245/s10434-009-0445-1