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A Novel Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Gastric Cancer Susceptibility in Taiwan

Annals of Surgical Oncology volume 15, pages 514–518 (2008)Cite this article

Abstract

Background

The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.

Materials and Methods

In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms’ association with gastric cancer susceptibility.

Results

We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47–9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.

Conclusions

Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.

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Acknowledgments

We thank Chia-Wen Tsai, Hsiu-Yun Liang, and Chiao-Lin Lin for their technical assistance. This study was supported by research grants from the China Medical University Hospital (DMR-96-002), Terry Fox Cancer Research Foundation and the National Science Council (NSC 95-2320-B-039-014-MY3, second year).

Author information

Affiliations

  1. Department of Hematology Oncology, China Medical University Hospital, Taichung, Taiwan, ROC

    Chang-Fang Chiu MD, PhD

  2. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, ROC

    Chang-Fang Chiu MD, PhD, Cheng-Li Wang MD, Nan-Yung Hsu MD, Jing-Ru Weng PhD & Da-Tian Bau PhD

  3. Medical College, China Medical University, Taichung, Taiwan, ROC

    Chang-Fang Chiu MD, PhD

  4. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan, ROC

    Chung-Hsing Wang MD

  5. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan, ROC

    Cheng-Chieh Lin MD, PhD

  6. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, ROC

    Da-Tian Bau PhD

Authors
  1. Chang-Fang Chiu MD, PhD
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  2. Chung-Hsing Wang MD
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  3. Cheng-Li Wang MD
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  4. Cheng-Chieh Lin MD, PhD
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  5. Nan-Yung Hsu MD
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  6. Jing-Ru Weng PhD
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  7. Da-Tian Bau PhD
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Corresponding author

Correspondence to Da-Tian Bau PhD.

Additional information

C.-F. Chiu and C.-H. Wang contributed equally to this study.

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Chiu, CF., Wang, CH., Wang, CL. et al. A Novel Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Gastric Cancer Susceptibility in Taiwan. Ann Surg Oncol 15, 514–518 (2008). https://doi.org/10.1245/s10434-007-9674-3

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  • DOI: https://doi.org/10.1245/s10434-007-9674-3

Keywords

  • XRCC4
  • Polymorphism
  • Gastric cancer
  • Carcinogenesis