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Prognosis of Patients Who Relapse after Fertility-Sparing Surgery in Epithelial Ovarian Cancer

  • Gynecologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The prognosis for patients who develop a recurrence after fertility-sparing surgery for epithelial ovarian cancer (EOC) remains unclear. This is the first study to evaluate survival in patients who have developed a recurrence in this context.

Methods

The outcomes of relapsed patients reported in the literature in the four main series of fertility-sparing surgery for EOC were reviewed and updated (where feasible).

Results

Twenty-three of the 166 patients in the series were reported to have recurrent disease. The site of the recurrence was the peritoneum (+/- remaining ovary) in 17 patients, and distant in six patients. Twelve patients died of recurrent disease, two are still alive with persistent disease, eight are disease-free, and one is alive but her exact status is not known. Among eight patients (34%) with an isolated recurrence on the remaining ovary, two died and one was lost to follow-up.

Conclusion

In this carefully monitored population, including systematic radiological examinations, the rate of isolated recurrences on the spared ovary is low. Recurrence in these patients carries a poor prognosis. Such results suggest that initial selection of candidates for fertility-sparing surgery should be carefully defined to reduce the rate of recurrences that carry a poor prognosis.

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ACKNOWLEDGMENT

We would like to thank Lorna Saint Ange for editing the text and Nicoletta Colombo for updating the outcomes of patients.

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Authors and Affiliations

  1. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif, FRANCE

    Olivier Marpeau MD, Yaelle Zafrani MD, Catherine Uzan MD, Sebastien Gouy MD, Catherine Lhommé MD & Philippe Morice MD

  2. Indiana University School of Medicine, Indianapolis, IN, Indiana, USA

    Jeanne Schilder MD

Authors
  1. Olivier Marpeau MD
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  2. Jeanne Schilder MD
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  3. Yaelle Zafrani MD
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  4. Catherine Uzan MD
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  5. Sebastien Gouy MD
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  6. Catherine Lhommé MD
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  7. Philippe Morice MD
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Corresponding author

Correspondence to Philippe Morice MD.

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Marpeau, O., Schilder, J., Zafrani, Y. et al. Prognosis of Patients Who Relapse after Fertility-Sparing Surgery in Epithelial Ovarian Cancer. Ann Surg Oncol 15, 478–483 (2008). https://doi.org/10.1245/s10434-007-9651-x

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  • DOI: https://doi.org/10.1245/s10434-007-9651-x

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