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Should Pelvic and Para-aortic Lymphadenectomy Be Different Depending on Histological Subtype in Epithelial Ovarian Cancer?

  • Gynecologic Oncology
  • Original Paper
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The aim of this study was to determine the influence of the different histological subtypes (serous versus non-serous) on the location of nodal metastases in patients undergoing pelvic and para-aortic lymphadenectomies during the initial management of epithelial ovarian tumors.

Methods

We carried out a retrospective analysis of data concerning patients fulfilling the following inclusion criteria: (1) an epithelial ovarian tumor; (2) a complete pelvic and bilateral para-aortic lymphadenectomy up to the level of the left renal vein; (3) surgical procedures including lymphadenectomies performed before adjuvant chemotherapy; and (4) a description of the distribution of positive nodes removed between pelvic and para-aortic areas. Patients were classified into two groups according to the histological subtypes: serous (group 1) and non-serous (group 2) tumors.

Results

Of patients treated between 1989 and 2005, 148 fulfilled the inclusion criteria: 73 had a serous tumor and 75 a non-serous tumor. Positive nodes were observed in 70 (47%) patients—47 (64%) in group 1 and 23 (31%) in group 2 (P < 0.05). But the distribution of involved nodes between pelvic and para-aortic areas in patients with positive nodes was not statistically different between the two groups. In both groups, the most common site for positive nodes in the para-aortic area was the left para-aortic group: 74% in group 1 and 61% in group 2 (NS).

Conclusions

This series suggests that the histological subtype has no impact on the distribution of positive nodes in pelvic and para-aortic areas in patients with epithelial ovarian tumors.

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Acknowledgements

We would like to acknowledge Lorna Saint Ange for editing this manuscript.

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Authors and Affiliations

  1. Service de Chirurgie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France

    Natacha Roger MD, Yaelle Zafrani MD, Catherine Uzan MD, Sebastien Gouy MD, Annie Rey MD, Patricia Pautier MD, Catherine Lhommé MD, Pierre Duvillard MD, Damienne Castaigne MD & Philippe Morice MD

  2. Universite Paris-Sud, Paris 11, France

    Philippe Morice MD

Authors
  1. Natacha Roger MD
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  2. Yaelle Zafrani MD
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  3. Catherine Uzan MD
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  4. Sebastien Gouy MD
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  5. Annie Rey MD
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  6. Patricia Pautier MD
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  7. Catherine Lhommé MD
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  8. Pierre Duvillard MD
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  9. Damienne Castaigne MD
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  10. Philippe Morice MD
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Corresponding author

Correspondence to Philippe Morice MD.

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Roger, N., Zafrani, Y., Uzan, C. et al. Should Pelvic and Para-aortic Lymphadenectomy Be Different Depending on Histological Subtype in Epithelial Ovarian Cancer?. Ann Surg Oncol 15, 333–338 (2008). https://doi.org/10.1245/s10434-007-9639-6

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  • DOI: https://doi.org/10.1245/s10434-007-9639-6

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