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h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma

  • Thoracic Oncology
  • Original Papers
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The human homologue of Drosophila prune (PRUNE, which encodes h-prune) protein interacts with glycogen synthase kinase 3 and promotes cell motility. The aim of our study was to investigate the impact of immunohistochemically detected h-prune expression on the survival of patients with esophageal squamous cell carcinoma (ESCC).

Methods

Immunohistochemical staining of h-prune was performed for 205 surgically resected specimens of ESCC.

Results

In total, 43 (21%) of 205 ESCC cases were positive for h-prune. h-prune-positive ESCC cases showed a more-advanced T stage (P < 0.0001), N stage (P < 0.0001), and tumor stage (P < 0.0001) than h-prune-negative ESCC cases. In the group of 116 stage II and III ESCC cases, recurrence of ESCC was frequently found in h-prune-positive cases. In patients with lung recurrence, the tumors were more likely to be h-prune positive than h-prune negative. Univariate analysis revealed that T stage (P < 0.0001), N stage (P < 0.0001), tumor stage (P < 0.0001), and h-prune staining (P < 0.0001) were significant prognostic factors for survival. Multivariate analysis indicated that N stage (P = 0.0182) and h-prune staining (P < 0.0001) were independent predictors for survival.

Conclusions

These results indicate that immunostaining of h-prune is useful to identify patients at high risk for recurrence or poor prognosis associated with ESCC.

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Acknowledgments

This work was supported, in part, by grants-in-aid for cancer research from the Ministry of Education, Culture, Science, Sports and Technology of Japan; and from the Ministry of Health, Labor, and Welfare of Japan. We thank Masayoshi Takatani and Masayuki Ikeda for excellent technical assistance and advice. This work was carried out with the kind cooperation of the research center for molecular medicine, faculty of medicine, Hiroshima University. We thank the analysis center of life science, Hiroshima University for the use of their facilities.

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Authors and Affiliations

  1. Department of Oncological Science (Surgery II), Oita University Faculty of Medicine, Oita, 879-5593, Japan

    Tsuyoshi Noguchi MD, PhD & Shinsuke Wada MD, PhD

  2. Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Naohide Oue MD, PhD, Kazuhiro Sentani MD, Naoya Sakamoto MD & Wataru Yasui MD, PhD

  3. Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan

    Akira Kikuchi MD, PhD

Authors
  1. Tsuyoshi Noguchi MD, PhD
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  2. Naohide Oue MD, PhD
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  3. Shinsuke Wada MD, PhD
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  4. Kazuhiro Sentani MD
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  5. Naoya Sakamoto MD
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  6. Akira Kikuchi MD, PhD
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  7. Wataru Yasui MD, PhD
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Corresponding author

Correspondence to Wataru Yasui MD, PhD.

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Noguchi, T., Oue, N., Wada, S. et al. h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 16, 1390–1396 (2009). https://doi.org/10.1245/s10434-007-9585-3

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  • DOI: https://doi.org/10.1245/s10434-007-9585-3

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