Skip to main content

Advertisement

SpringerLink
Log in

Can Completion Lymph Node Dissection Be Avoided for a Positive Sentinel Node in Melanoma?

  • Melanomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Elashoff R, Essner R, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Reintgen DS, Coventry BJ, Glass EC, Wang HJ, MSLT Group. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 2006; 355:1307–17

    Article  PubMed  CAS  Google Scholar 

  2. Morton DL, Cochran AJ, Thompson JF, Elashoff R, Essner R, Glass EC, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Reintgen DS, Coventry BJ, Wang HJ, Multicenter Selective Lymphadenectomy Trial Group. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg 2005; 242:302–11

    PubMed  Google Scholar 

  3. Cochran AJ, Wen DR, Huang RR, Wang HJ, Elashoff R, Morton DL. Prediction of metastatic melanoma in nonsentinel nodes and clinical outcome based on the primary melanoma and the sentinel node. Mod Pathol 2004; 17:747–55

    Article  PubMed  Google Scholar 

  4. Cascinelli N, Bombardieri E, Bufalino R, et al. Sentinel and nonsentinel node status in stage IB and II melanoma patients: two-step prognostic indicators of survival. J Clin Oncol 2006; 24:4464–71

    Article  PubMed  Google Scholar 

  5. Govindarajan A, Ghazarian DM, McCready DR, Leong WL. Histological features of melanoma sentinel lymph node metastases associated with status of the completion lymphadenectomy and rate of subsequent relapse. Ann Surg Oncol 2007; 14:906–12

    Article  PubMed  Google Scholar 

  6. Starz H, Balda BR, Kramer KU, Buchels H, Wang H. A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma. Cancer 2001; 91:2110–21

    Article  PubMed  CAS  Google Scholar 

  7. Scolyer RA, Li LX, McCarthy SW, Shaw HM, Stretch JR, Sharma R, Thompson JF. Micromorphometric features of positive sentinel lymph nodes predict involvement of nonsentinel nodes in patients with melanoma. Am J Clin Pathol 2004; 122:532–9

    Article  PubMed  Google Scholar 

  8. Dewar DJ, Newell B, Green MA, Topping AP, Powell BW, Cook MG. The microanatomic location of metastatic melanoma in sentinel lymph nodes predicts nonsentinel lymph node involvement. J Clin Oncol 2004; 22:3345–9

    Article  PubMed  CAS  Google Scholar 

  9. Reeves ME, Delgado R, Busam KJ, Brady MS, Coit DG. Prediction of nonsentinel lymph node status in melanoma. Ann Surg Oncol 2003; 10:27–31

    Article  PubMed  Google Scholar 

  10. Lee JH, Essner R, Torisu-Itakura H, Wanek L, Wang H, Morton DL. Factors predictive of tumor-positive nonsentinel lymph nodes after tumor-positive sentinel lymph node dissection for melanoma. J Clin Oncol 2004; 22:3677–84

    Article  PubMed  Google Scholar 

  11. Sabel MS, Griffith K, Sondak VK, Lowe L, Schwartz JL, Cimmino VM, Chang AE, Rees RS, Bradford CR, Johnson TM. Predictors of nonsentinel lymph node positivity in patients with a positive sentinel node for melanoma. J Am Coll Surg 2005; 201:37–47

    Article  PubMed  Google Scholar 

  12. Vuylsteke RJ, Borgstein PJ, van Leeuwen PA, Gietema HA, Molenkamp BG, Statius Muller MG, van Diest PJ, van der Sijp JR, Meijer S. Sentinel lymph node tumor load: an independent predictor of additional lymph node involvement and survival in melanoma. Ann Surg Oncol 2005; 12:440–8

    Article  PubMed  Google Scholar 

  13. Palmieri G, Ascierto PA, Cossu A, Mozzillo N, Motti ML, Satriano SM, Botti G, Caraco C, Celentano E, Satriano RA, Lissia A, Tanda F, Pirastu M, Castello G, Melanoma Cooperative Group. Detection of occult melanoma cells in paraffin-embedded histologically negative sentinel lymph nodes using a reverse transcriptase polymerase chain reaction assay. J Clin Oncol 2001; 19:1437–43

    PubMed  CAS  Google Scholar 

  14. Takeuchi H, Morton DL, Kuo C, Turner RR, Elashoff D, Elashoff R, Taback B, Fujimoto A, Hoon DS. Prognostic significance of molecular upstaging of paraffin-embedded sentinel lymph nodes in melanoma patients. J Clin Oncol 2004; 22:2671–80

    Article  PubMed  CAS  Google Scholar 

  15. Wong SL, Morton DL, Thompson JF, Gershenwald JE, Leong SP, Reintgen DS, Gutman H, Sabel MS, Carlson GW, McMasters KM, Tyler DS, Goydos JS, Eggermont AM, Nieweg OE, Cosimi AB, Riker AI, Coit GD. Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study. Ann Surg Oncol 2006; 13:809–16

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, CA, USA

    Donald L. Morton MD & Randall P. Scheri MD

  2. Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Charles M. Balch MD

Authors
  1. Donald L. Morton MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Randall P. Scheri MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles M. Balch MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Donald L. Morton MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morton, D.L., Scheri, R.P. & Balch, C.M. Can Completion Lymph Node Dissection Be Avoided for a Positive Sentinel Node in Melanoma?. Ann Surg Oncol 14, 2437–2439 (2007). https://doi.org/10.1245/s10434-007-9474-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-007-9474-9

Search

Navigation