Skip to main content
SpringerLink
Log in

Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer

  • Endocrine Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Aims and Background

The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy.

Methods

Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied.

Results

Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05).

Conclusion

In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berlett BS, Stadtman ER. Protein oxidation in aging, disease and oxidative stress. J. Biol. Chem. 1997; 272:20313–6

    Article  PubMed  CAS  Google Scholar 

  2. Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 1998; 30:225–43

    PubMed  CAS  Google Scholar 

  3. Witko-Sarsat V, Friedlander M, Capeller-Blandin C, et al. AOPP as novel marker of oxidative stress in uremia. Kidney Int 1996; 49:1304–13

    Article  PubMed  CAS  Google Scholar 

  4. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. British Med. Bull. 1993; 49:481–93

    CAS  Google Scholar 

  5. Loeckie LZ, Meerman JHN, Commandeur JNM. Biomarkers of free radical damage: applications in experimental animals and in humans. Free Radic Biol Med 1999; 26:202–6

    Article  Google Scholar 

  6. Zadeh-Nourooz J, Tajaddini-Sarmadi J, Wolff S. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal Biochem 1994; 220:403–9

    Article  Google Scholar 

  7. Apps DK, Cohen BB, Steel CM. Amino acid metabolism. Biochemistry: A Concise Text for Medical Students, 5th ed. London: Bailliere Tindall; 1992;176–7

    Google Scholar 

  8. Dumitrescu C, Belgun M, Olinescu R, et al. Effect of vitamin C administration on the ratio between the pro and antioxidative factors. Rom J Endocrinol 1993; 31(1-2):81–4

    PubMed  CAS  Google Scholar 

  9. Lenzen S, Drinkgern J, Tiedege M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissue. Free Rad. Biol Med 1996; 20:463–6

    Article  PubMed  CAS  Google Scholar 

  10. Mano T, Shinohara R, Iwase K, et al. Changes in free radical scavengers and lipid peroxide in thyroid glands of various thyroid disorders. Horm Metab Res 1997; 29(7):351–4

    Article  PubMed  CAS  Google Scholar 

  11. Sadani GR, Nadkarni GD. Role of tissue antioxidant defence in thyroid cancers. Cancer Lett 1996; 109(1–2):231–5

    Article  PubMed  CAS  Google Scholar 

  12. Halliwell B, Clement MV, Long LH, et al. Hydrogen peroxide in the human body. FEBS Lett 2000; 486:10–3

    Article  PubMed  CAS  Google Scholar 

  13. Wolf SP. Ferrous ion oxidation in presence of xylenol orange for measurement of hydroperoxides. Methods Enzymol 1984; 223:182–9

    Google Scholar 

  14. Droge W. Free radicals in the physiological control of cell function Physiol Rev 2002; 82:47–95

    PubMed  CAS  Google Scholar 

  15. Alderman Ch J, Shah S, Foreman JC. The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radical Biol Med 2002; 32:377–385

    Article  Google Scholar 

  16. Loeckie LZ, Meerman JHN, Commandeur JNM. Biomarkers of free radical damage: applications in experimental animals and in humans. Free Radic Biol Med 1999; 26:202–26

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Celal Bayar University, Manisa, Turkey

    Funda Kosova

  2. Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey

    Bahadır Çetin, Melih Akıncı, Sabahattin Aslan & Abdullah Çetin

  3. Department of Medical Biochemistry, Gazi University, School of Medicine, Ankara, Turkey

    Aylin Sepici & Nilgün Altan

  4. Department of Biochemistry and Clinical Biochemistry, Celal Bayar University, School of Medicine, Manisa, Turkey

    Zeki Arı

Authors
  1. Funda Kosova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bahadır Çetin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Melih Akıncı
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sabahattin Aslan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zeki Arı
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Aylin Sepici
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nilgün Altan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Abdullah Çetin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Funda Kosova.

Additional information

This study was presented in Clinical Biochemistry Congress at November 1–4,2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kosova, F., Çetin, B., Akıncı, M. et al. Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer. Ann Surg Oncol 14, 2616–2620 (2007). https://doi.org/10.1245/s10434-007-9425-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-007-9425-5

Keywords

Search

Navigation