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Expression and Prognostic Value of MG7-Ag in Patients With Surgically Resectable Esophageal Squamous Cell Carcinoma

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

MG7-Ag is a human gastric-carcinoma-associated antigen. The expression of MG7-Ag was found to increase gradually with the development and progression of gastric cancer. Moreover, a poorer prognosis was found in MG7-Ag positive gastric-carcinoma patients than in MG7-Ag negative patients. However, neither MG7-Ag expression nor its clinical significance has been previously examined in squamous cell carcinoma (SCC) of the esophagus. In this study, we examined the expression of MG7-Ag in esophageal squamous cell carcinomas to assess its value as a prognostic indicator.

Methods

The expression of MG7-Ag was detected in 112 cases of esophageal squamous cell carcinoma (SCC) by immunohistochemical analysis. The relation of MG7-Ag staining with various clinicopathological features was statistically analyzed.

Results

The staining of MG7-Ag was detected in SCC, while not in normal epithelial cells. In esophageal SCC, MG7-Ag was found significantly correlated with depth of invasion (P = .012), in T4, T3 carcinomas but not in T2, T1 carcinomas, lymph node metastases (P = .029), pathological stage (P = .005). Consistently, the survival rate tended to be statistically lower in patients with MG7-Ag positive SCCs than in MG7-Ag negative SCCs (P = .005). However, no significant difference was observed between MG7-expression and patient age, sex, tumor location, differentiation, distant metastasis, and lymphatic invasion.

Conclusion

MG7-Ag might play a positive role in the process of carcinogenesis and progression of esophageal SCC, and it could be considered as one valuable prognostic indicator in esophageal SCC.

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Acknowledgment

We thank Mr. Zenpeng Li (Department of Pathology, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing, China) for his excellent technical assistance and Mr. Yunming Li (Department of Health Statistics, The Fourth Military Medical University, Xi’an, P.R. China) for his statistical analysis assistance.

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Authors and Affiliations

  1. State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an, P.R. China

    Yunping Zhao, Xin Wang, Bin Jin, Yuanyuan Lu, Taidong Qiao, Liu Hong & Daiming Fan MD, PhD

  2. Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China

    Yunping Zhao, Yaoguang Jiang, Ruwen Wang & Xiushan Zheng

Authors
  1. Yunping Zhao
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  2. Yaoguang Jiang
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  3. Ruwen Wang
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  4. Xiushan Zheng
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  5. Xin Wang
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  6. Bin Jin
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  7. Yuanyuan Lu
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  8. Taidong Qiao
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  9. Liu Hong
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  10. Daiming Fan MD, PhD
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Correspondence to Daiming Fan MD, PhD.

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Zhao, Y., Jiang, Y., Wang, R. et al. Expression and Prognostic Value of MG7-Ag in Patients With Surgically Resectable Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 14, 2621–2627 (2007). https://doi.org/10.1245/s10434-007-9416-6

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  • DOI: https://doi.org/10.1245/s10434-007-9416-6

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