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Recurrence and Survival Outcomes after Hepatic Resection with or without Cryotherapy for Liver Metastases from Colorectal Carcinoma

  • Hepatic and Pancreatic
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Some reports support resection combined with cryotherapy for patients with multiple bilobar colorectal liver metastases (CRLM) that would otherwise be ineligible for curative treatments. This series demonstrates long-term results of 415 patients with CRLM who underwent resection with or without cryotherapy.

Methods

Between April 1990 and January 2006, 291 patients were treated with resection only and 124 patients with combined resection and cryotherapy. Recurrence and survival outcomes were compared. Kaplan-Meier and Cox-regression analyses were used to identify significant prognostic indicators for survival.

Results

Median length of follow-up was 25 months (range 1–124 months). The 30-day perioperative mortality rate was 3.1%. Overall median survival was 32 months (range 1–124 months), with 1-, 3- and 5-year survival values of 85%, 45% and 29%, respectively. The overall recurrence rates were 66% and 78% for resection and resection/cryotherapy groups, respectively. For the resection group, the median survival was 34 months, with 1-, 3- and 5- year survival values of 88%, 47% and 32%, respectively. The median survival for the resection/cryotherapy group was 29 months, with 1-, 3- and 5-year survival values of 84%, 43% and 24%, respectively (P = 0.206). Five factors were independently associated with an improved survival: absence of extrahepatic disease at diagnosis, well- or moderately-differentiated colorectal cancer, largest lesion size being 4 cm or less, a postoperative CEA of 5 ng/ml or less and absence of liver recurrence.

Conclusions

Long-term survival results of resection combined with cryotherapy for multiple bilobar CRLM are comparable to that of resection alone in selected patients.

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Authors and Affiliations

  1. Department of Surgery, University of New South Wales, St George Hospital, Sydney, NSW, 2217, Australia

    Rui Niu BSc (Med), Tristan D. Yan BSc (Med), MBBS, Jacqui C. Zhu BSc (Med), Francis Chu MBBS & David L. Morris MD, PhD

  2. School of Public Health and Community Medicine, Sydney, Australia

    Deborah Black BSc, DipEd, MStat, PhD

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  1. Rui Niu BSc (Med)
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  2. Tristan D. Yan BSc (Med), MBBS
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  3. Jacqui C. Zhu BSc (Med)
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  4. Deborah Black BSc, DipEd, MStat, PhD
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  5. Francis Chu MBBS
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  6. David L. Morris MD, PhD
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Correspondence to David L. Morris MD, PhD.

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Niu, R., Yan, T.D., Zhu, J.C. et al. Recurrence and Survival Outcomes after Hepatic Resection with or without Cryotherapy for Liver Metastases from Colorectal Carcinoma. Ann Surg Oncol 14, 2078–2087 (2007). https://doi.org/10.1245/s10434-007-9400-1

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  • DOI: https://doi.org/10.1245/s10434-007-9400-1

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