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Treatment Failure After Percutaneous Radiofrequency Ablation for Nonsurgical Candidates With Pulmonary Metastases From Colorectal Carcinoma

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Abstract

Background

This study critically evaluated the local and overall treatment failure rates after percutaneous radiofrequency ablation (RFA) of pulmonary metastases from colorectal carcinoma.

Methods

Fifty-five nonsurgical candidates underwent RFA of colorectal pulmonary metastases. The primary end points of this study were local progression-free survival (PFS) and overall PFS. Univariate and multivariate analyses were performed to identify significant prognostic parameters for local and overall PFS.

Results

The local recurrence rate was 38%. For local PFS, univariate analysis demonstrated that the largest size of lung metastasis, the location of lung metastases, the post-RFA carcinoembryonic antigen level at 1 month, and the post-RFA carcinoembryonic antigen level at 3 months were significant prognostic indicators. In multivariate analysis, a largest size of lung metastasis of >3 cm and a post-RFA carcinoembryonic antigen level of >5 ng/mL at 1 month were independently associated with a reduced local PFS. The overall recurrence rate was 66%. For overall PFS, univariate analysis demonstrated that sex and the largest size of lung metastasis were significant prognostic indicators. In multivariate analysis, a largest size of lung metastasis of >3 cm was independently associated with a reduced overall PFS.

Conclusions

RFA of colorectal pulmonary metastases may have a useful role in local disease control for nonsurgical candidates, but its efficacy in patients with a lung metastasis of >3 cm is limited.

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Acknowledgments

The authors thank David Chang for his expertise in statistical analysis and Jing Zhao for maintaining the RFA database.

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Authors and Affiliations

  1. Department of Surgery, University of New South Wales, St. George Hospital, Sydney, New South Wales, 2217, Australia

    Tristan D. Yan BSc (Med), MBBS, Julie King MPH, Adrian Sjarif BSc (Med), MBBS, Karin Steinke MD, Ahmed Al-Kindy MD & David L. Morris MD, PhD

  2. Department of Radiology, University of New South Wales, St. George Hospital, Sydney, New South Wales, 2217, Australia

    Derek Glenn MBBS & Karin Steinke MD

Authors
  1. Tristan D. Yan BSc (Med), MBBS
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  2. Julie King MPH
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  3. Adrian Sjarif BSc (Med), MBBS
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  4. Derek Glenn MBBS
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  5. Karin Steinke MD
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  6. Ahmed Al-Kindy MD
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  7. David L. Morris MD, PhD
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Corresponding author

Correspondence to David L. Morris MD, PhD.

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Yan, T.D., King, J., Sjarif, A. et al. Treatment Failure After Percutaneous Radiofrequency Ablation for Nonsurgical Candidates With Pulmonary Metastases From Colorectal Carcinoma. Ann Surg Oncol 14, 1718–1726 (2007). https://doi.org/10.1245/s10434-006-9271-x

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  • DOI: https://doi.org/10.1245/s10434-006-9271-x

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