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The Landmark Series: Management of Small Bowel Neuroendocrine Tumors

  • Endocrine Tumors
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Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen survival. In advanced NETs, improvement in progression-free survival has been reported in large, randomized, controlled trials of various medical treatments, including somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy. This review discusses important studies influencing the management of SBNETs and the limitations of current evidence regarding surgical interventions for SBNETs.

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Acknowledgment

This work was supported by NIH Grants T32 CA148062 (CGT), T32 CA078586 (SKS), and Specialized Programs of Research Excellence Grant P50 CA174521-01 (JRH).

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  1. Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA

    Catherine G. Tran MD, Scott K. Sherman MD & James R. Howe MD

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  1. Catherine G. Tran MD
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This work was supported by NIH Grants T32 CA148062 (CGT), T32 CA078586 (SKS), and Specialized Programs of Research Excellence Grant P50 CA174521-01 (JRH).

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Tran, C.G., Sherman, S.K. & Howe, J.R. The Landmark Series: Management of Small Bowel Neuroendocrine Tumors. Ann Surg Oncol 28, 2741–2751 (2021). https://doi.org/10.1245/s10434-020-09566-4

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