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KRAS Mutation Predicted More Mirometastases and Closer Resection Margins in Patients with Colorectal Cancer Liver Metastases

  • Qiongyan Zhang
  • Junjie Peng
  • Min Ye
  • Weiwei Weng
  • Cong Tan
  • Shujuan Ni
  • Dan Huang
  • Weiqi ShengEmail author
  • Lei WangEmail author
Hepatobiliary Tumors
  • 37 Downloads

Abstract

Background

The presence of micrometastases is a source of recurrence after surgical resection of colorectal liver metastases (CRLM). The KRAS mutation is common in colorectal cancer, however the correlation between KRAS status and micrometastases has not been thoroughly clarified.

Methods

We enrolled a cohort of 251 consecutive CRLM patients who received complete liver surgery with known KRAS mutation status, and collected clinicopathological information, including micrometastases, margin status, preoperative chemotherapy, and liver recurrence-free survival (LRFS) and overall survival (OS) rates.

Results

KRAS-mutant (mutKRAS) patients had a higher incidence (60.3 vs. 40.8%; p = 0.002) and higher number of micrometastases [2.0 (range 0–38.0) vs. 0 (range 0–15.0); p < 0.001] than KRAS wild-type (wtKRAS) patients. The micrometastases in the mutKRAS group were more distant than those in the wtKRAS group [0.7 (range 0.1–9.0) vs. 0.6 (range 0.2–5.0) mm; p = 0.018). The mutKRAS group had more involved margin resections (21.5 vs. 9.2%; p = 0.07) and narrower margin widths [2.0 (range 0–40.0) vs. 4.3 (0–50.0) mm; p = 0.002] than the wtKRAS group. In addition, preoperative chemotherapy was associated with a lower rate of micrometastases in mutKRAS CRLM tumors (p < 0.05). mutKRAS status, positive margins, and micrometastases were all related to worse LRFS and OS (p < 0.05); however, micrometastases were not significantly correlated with OS in the multivariate analysis (p = 0.106).

Conclusions

mutKRAS patients had more micrometastases, increased R1 resections, and narrower margins. The presence of micrometastases may have led to the narrow margin width observed in these cases.

Notes

Author’s contributions

QZ analyzed the data and wrote the original draft of the manuscript. JP provided suggestions for data interpretation. MY and WW collected the follow-up patient information. CT provided methodology suggestions. DH and SN reviewed the pathological features. WS designed the study, critically revised the article, obtained funding, and is responsible for the study. LW designed the study, analyzed the data, obtained funding, and is responsible for the study.

Funding

This study was supported by the Natural Science Foundation of Shanghai (17ZR1406500, 18ZR1408000), Shanghai Hospital Development Center Emerging Advanced Technology Joint Research Project (HDC12014105), and Shanghai Key Developing Disciplines (2015ZB0201).

Disclosure

Qiongyan Zhang, Junjie Peng, Min Ye, Weiwei Weng, Cong Tan, Shujuan Ni, Dan Huang, Weiqi Sheng, and Lei Wang declare they have no conflicts of interest.

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Qiongyan Zhang
    • 1
    • 2
    • 3
  • Junjie Peng
    • 4
    • 2
  • Min Ye
    • 1
    • 2
  • Weiwei Weng
    • 1
    • 2
  • Cong Tan
    • 1
    • 2
  • Shujuan Ni
    • 1
    • 2
  • Dan Huang
    • 1
    • 2
  • Weiqi Sheng
    • 1
    • 2
    Email author
  • Lei Wang
    • 1
    • 2
    Email author
  1. 1.Department of PathologyFudan University Shanghai Cancer CenterShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Pathology, Zhongshan HospitalFudan UniversityShanghaiChina
  4. 4.Department of Colorectal SurgeryFudan University Shanghai Cancer CenterShanghaiChina

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