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Association Between Preoperative Muscle Mass and Intraoperative Bacterial Translocation in Patients Undergoing Hepatectomy, Pancreatoduodenectomy, and Esophagectomy

  • Kumiko Akashi
  • Yukihiro YokoyamaEmail author
  • Takashi Mizuno
  • Tetsuya Abe
  • Masahide Fukaya
  • Takashi Asahara
  • Masato Nagino
Translational Research and Biomarkers
  • 27 Downloads

Abstract

Purpose

This study investigated the correlation between the fecal profile and muscle mass, which has not been elucidated before.

Methods

This study included patients who underwent hepatectomy, pancreatoduodenectomy, or esophagectomy and had fecal samples collected preoperatively and mesenteric lymph nodes (MLNs) harvested intraoperatively to determine the fecal profile and presence of bacteria in the MLNs. Total psoas area (TPA) was measured at the third lumbar vertebra using preoperative computed tomography images. TPA was standardized by body surface area (BSA) using the following equation: standardized TPA (mm2/m2) (stTPA) = TPA (mm2)/BSA (m2). The fecal concentrations of representative microorganisms and organic acids also were measured.

Results

A total of 127 patients undergoing hepatectomy (n = 48), pancreatoduodenectomy (n = 44), and esophagectomy (n = 35) were included. The fecal levels of predominant obligate anaerobes showed a positive correlation with stTPA, whereas that of pathogenic microorganisms showed a negative correlation with stTPA. The fecal concentrations of total short chain fatty acids (the sum of acetic acid, propionic acid, and butyric acid) also showed a positive correlation with stTPA. The stTPA was significantly lower in patients with positive microorganisms in the MLNs (patients with bacterial translocation) compared to those without microorganisms in the MLNs (p = 0.047).

Conclusions

This study was the first to demonstrate the association between muscle mass and the fecal profile, as well as their association with bacterial translocation.

Notes

Acknowledgment

The authors thank Eiji Nishigaki and Takashi Miyake, who dedicatedly collected the samples. The authors also thank Yukiko Kado and Akira Takahashi for their technical assistance in analyzing fecal and MLN samples.

Disclosure

The authors affirm that they have no financial or personal affiliations (including research funding) or other involvement with any commercial organization that has a direct financial interest in any matter included in this manuscript.

Supplementary material

10434_2019_7707_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 13 kb)

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Kumiko Akashi
    • 1
  • Yukihiro Yokoyama
    • 1
    • 2
    Email author
  • Takashi Mizuno
    • 1
  • Tetsuya Abe
    • 3
  • Masahide Fukaya
    • 1
  • Takashi Asahara
    • 4
  • Masato Nagino
    • 1
  1. 1.Division of Surgical Oncology, Department of SurgeryNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of Perioperative MedicineNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of Gastroenterological SurgeryAichi Cancer CenterNagoyaJapan
  4. 4.Yakult Central InstituteTokyoJapan

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