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Annals of Surgical Oncology

, Volume 26, Issue 12, pp 3962–3971 | Cite as

Characteristics Associated with Pathologic Nodal Burden in Patients Presenting with Clinical Melanoma Nodal Metastasis

  • Minyoung Kwak
  • Yun Song
  • Phyllis A. Gimotty
  • Norma E. Farrow
  • Andrew D. Tieniber
  • Jonathan G. Davick
  • Gabriella N. Tortorello
  • Georgia M. Beasley
  • Craig L. SlingluffJr.
  • Giorgos C. KarakousisEmail author
Melanoma

Abstract

Background

Nodal observation is safe for patients with microscopic melanoma metastasis in a sentinel lymph node (LN). Complete LN dissection (CLND) remains the standard of care for patients with clinically evident LN (cLN) metastases, even though about 40% have only one pathologic LN (pLN). We sought to identify clinical features associated with having one pLN among patients with cLNs.

Methods

Patients at three melanoma centers who underwent CLND for cLNs were identified. Clinicopathologic and imaging characteristics associated with one pLN were determined by multivariable logistic regression and classification tree analysis.

Results

Of 190 patients, 90 (47.4%) had one pLN and 100 (52.6%) had more than one pLN. By multivariable logistic regression, extremity versus truncal primary (odds ratio [OR] 2.15, p = 0.012), axillary versus superficial inguinal location (OR 3.89, p = 0.009), and preoperative cross-sectional imaging demonstrating more than one versus one cLN (OR 17.1, p < 0.001) were associated with more than one pLN. The negative predictive value for additional pathologic nodal disease of preoperative imaging was 70.9%, increasing to 74.4% for positron emission tomography/computed tomography. In the subgroup of patients with one cLN, the classification tree identified two groups with < 10% risk of additional pLNs: (1) Breslow thickness > 6.55 mm (n = 17); and (2) if unknown primary or Breslow thickness ≤ 6.55 mm, then LN diameter > 1.8 cm in the inguinal location (n = 22).

Conclusion

The majority of patients with one cLN from melanoma by preoperative imaging will harbor no additional pathologic nodes on CLND. Safety of nodal observation after clinical nodal excision in these patients, particularly in an era of effective adjuvant therapies, deserves prospective evaluation.

Notes

Funding

Partial funding was provided by National Cancer Institute (Grant Nos. T32-CA009109-41 and T32-CA009111), by a Farrow Fellowship, and by the Rebecca Clay Harris Memorial Fellowship.

Disclosures

Minyoung Kwak, Yun Song, Phyllis A. Gimotty, Norma E. Farrow, Andrew D. Tieniber, Jonathan G. Davick, Gabriella N. Tortorello, Georgia M. Beasley, Craig L. Slingluff Jr, and Giorgos C. Karakousis have no relevant conflicts of interest or disclosures to declare.

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Minyoung Kwak
    • 1
  • Yun Song
    • 2
  • Phyllis A. Gimotty
    • 3
  • Norma E. Farrow
    • 4
  • Andrew D. Tieniber
    • 2
  • Jonathan G. Davick
    • 5
  • Gabriella N. Tortorello
    • 2
  • Georgia M. Beasley
    • 4
  • Craig L. SlingluffJr.
    • 1
  • Giorgos C. Karakousis
    • 2
    Email author
  1. 1.Department of SurgeryUniversity of Virginia Health SystemCharlottesvilleUSA
  2. 2.Department of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Biostatistics, Epidemiology, and InformaticsUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Department of SurgeryDuke University School of MedicineDurhamUSA
  5. 5.Department of PathologyUniversity of Virginia Health SystemCharlottesvilleUSA

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