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Annals of Surgical Oncology

, Volume 26, Issue 11, pp 3727–3735 | Cite as

Prognostic Significance of Skeletal Muscle Loss During Early Postoperative Period in Elderly Patients with Esophageal Cancer

  • Keita Takahashi
  • Masayuki WatanabeEmail author
  • Ryotaro Kozuki
  • Tasuku Toihata
  • Akihiko Okamura
  • Yu Imamura
  • Shinji Mine
  • Naoki Ishizuka
Thoracic Oncology

Abstract

Background

Skeletal muscle loss during the early postoperative period frequently occurs during post-esophagectomy. Preoperative sarcopenia is a known prognostic factor. However, the prognostic significance of postoperative skeletal muscle loss remains unclear. This study was designed to clarify the impact of skeletal muscle loss during the early postoperative period on the prognosis of elderly patients undergoing esophagectomy.

Methods

We included 316 patients (age ≥ 65 years) who underwent esophagectomy. The skeletal muscle index (SMI) at the third lumber vertebra’s bottom level was measured using computed tomography (CT) before surgery and 4 months after surgery. The SMI reduction rate, patient’s prognosis, and recurrence rates were evaluated.

Results

The SMI reduction rates in tertiles were < 1.25% in the first tertile (t1, n = 105), between 1.25 and 9.13% in the second tertile (t2, n = 106), and > 9.13% in the third tertile (t3, n = 105). Both relapse-free survival (RFS) and overall survival (OS) in t3 were significantly worse than those in t1 and t2 (p < 0.001). Therefore, we defined t3 as the massive reduction (MR) group and t1 and t2 as the limited reduction (LR) group. By univariate analysis, both RFS and OS were significantly poorer in the MR group than in LR. By multivariate analysis, the massive skeletal muscle loss during the early postoperative period was an independent factor for both RFS and OS.

Conclusions

Early postoperative skeletal muscle loss predicts both recurrence and poor survival.

Notes

Disclosure

The authors have nothing to disclose.

Supplementary material

10434_2019_7616_MOESM1_ESM.tif (620 kb)
Supplemental Fig. 1 Study population (TIFF 619 kb)
10434_2019_7616_MOESM2_ESM.tif (2.1 mb)
Supplemental Fig. 2 The method to assess skeletal muscle mass (green area); skeletal muscle index = skeletal muscle mass/height2 (cm2/m2) (TIFF 2186 kb)
10434_2019_7616_MOESM3_ESM.docx (70 kb)
Supplementary material 3 (DOCX 70 kb)

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Keita Takahashi
    • 1
  • Masayuki Watanabe
    • 1
    Email author
  • Ryotaro Kozuki
    • 1
  • Tasuku Toihata
    • 1
  • Akihiko Okamura
    • 1
  • Yu Imamura
    • 1
  • Shinji Mine
    • 1
  • Naoki Ishizuka
    • 2
  1. 1.Department of Gastroenterological SurgeryThe Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan
  2. 2.Department of Clinical Trial Planning and ManagementThe Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan

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