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Annals of Surgical Oncology

, Volume 26, Issue 1, pp 118–124 | Cite as

Outcomes of Low-Grade Appendiceal Mucinous Neoplasms with Remote Acellular Mucinous Peritoneal Deposits

  • Campbell S. Roxburgh
  • Yaniv M. Fenig
  • Andrea Cercek
  • Jinru Shia
  • Rachel M. Rassam
  • Philip B. Paty
  • Garrett M. NashEmail author
Gastrointestinal Oncology
  • 155 Downloads

Abstract

Background

Occasionally, low-grade appendiceal mucinous neoplasms (LAMN) present with mucinous peritoneal deposits (MPD) localized to periappendiceal tissue or diffused throughout the peritoneum.

Objective

This study was aimed at evaluating the relevance of mucin cellularity for predicting outcomes of LAMN with remote MPD.

Methods

The records of patients with LAMN and remote MPD who underwent initial assessment at a comprehensive cancer center from 1990 to 2015 were reviewed, and diagnostic procedures, treatments, and outcomes were analyzed.

Results

Of 48 patients included in the analysis, 19 had cellular MPD (CMPD) and 29 had acellular MPD. Of 33 patients who underwent cytoreductive surgery, 30 had a complete cytoreduction; the 3 patients with an incomplete cytoreduction had CMPD. In the follow-up period (median, 4 years), 6 patients died of the disease, all of whom had CMPD. Of 11 patients who had progression of disease, 10 had CMPD.

Conclusion

Cellularity of remote MPD is an important determinant of disease outcome in LAMN. Approaches such as active surveillance may have a role in selected patients with LAMN and AMPD.

Notes

Acknowledgement

This study was supported in part by Grant P30 CA008748 from the National Cancer Institute.

Disclosure

Campbell S. Roxburgh, Yaniv M. Fenig, Andrea Cercek, Jinru Shia, Rachel M. Rassam, Philip B. Paty, and Garrett M. Nash have no conflicts of interest to declare.

Supplementary material

10434_2018_7003_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 15 kb)
10434_2018_7003_MOESM2_ESM.docx (38 kb)
Supplementary material 2 (DOCX 38 kb)
10434_2018_7003_MOESM3_ESM.pdf (1.4 mb)
Supplementary material 3 (PDF 1428 kb)

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Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  • Campbell S. Roxburgh
    • 1
    • 2
  • Yaniv M. Fenig
    • 1
    • 3
  • Andrea Cercek
    • 4
  • Jinru Shia
    • 5
  • Rachel M. Rassam
    • 1
  • Philip B. Paty
    • 1
  • Garrett M. Nash
    • 1
    Email author
  1. 1.Department of SurgeryMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Institute of Cancer Sciences, College of Medical, Veterinary and Life SciencesUniversity of GlasgowGlasgowUK
  3. 3.Department of SurgeryMonmouth Medical CenterLong BranchUSA
  4. 4.Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA
  5. 5.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA

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