Annals of Surgical Oncology

, Volume 26, Issue 1, pp 217–229 | Cite as

The Differences in Clinicopathologic and Prognostic Characteristics Between Surgically Resected Peripheral and Central Lung Squamous Cell Carcinoma

  • Mong-Wei Lin
  • Yen-Lin Huang
  • Ching-Yao Yang
  • Shuenn-Wen Kuo
  • Chen-Tu WuEmail author
  • Yih-Leong ChangEmail author
Thoracic Oncology



Pulmonary peripheral-type squamous cell carcinoma (p-SqCC) has been increasing in incidence. However, little is known about the clinicopathologic features of p-SqCC. This study aimed to investigate the clinicopathologic characteristics and clinical outcomes of p-SqCC compared with central-type SqCC (c-SqCC) in a large cohort of surgically resected lung SqCC patients with long-term follow-up results.


The study included 268 patients with SqCC who underwent surgical resection at the authors’ institute from January 1990 to September 2013. The mean follow-up period was 67.1 months. The clinicopathologic and genetic characteristics were investigated in relation to their association with progression-free survival (PFS) and overall survival (OS) based on tumor location.


The study cohort included 120 patients with p-SqCC and 148 patients with c-SqCC. Compared with c-SqCC, p-SqCC was correlated with older age (p = 0.002), female sex (p = 0.033), better performance status (p < 0.001), smaller tumor (p = 0.004), less lymph node metastasis (p < 0.001), and an earlier pathologic stage (p < 0.001). Despite the clinicopathologic differences, tumor location was not significantly correlated with clinical outcomes. For the p-SqCC patients, the multivariate analysis showed a significant correlation of lymphovascular invasion (PFS, p < 0.001; OS, p < 0.001) and lymph node metastasis (p = 0.007; OS, p = 0.022) with poor PFS and OS, but a significant correlation of incomplete tumor resection (PFS, p = 0.009) only with poor PFS.


The clinicopathologic features differed between the p-SqCC and c-SqCC patients. Lymphovascular invasion and lymph node metastasis were independent prognostic factors of p-SqCC. These prognostic factors may be potentially used as indicators for adjuvant therapies to be used with patients who have p-SqCC.



The authors thank Professor Yung-Chie Lee (23 October 1948 to 30 December 2010), a pioneer and leader of thoracic surgery in Taiwan, for his substantial contribution to patient care and surgery. The authors also thank Chih-Hsin Chen for her skillful technical support and clinical data collection. This study was funded by the National Taiwan University Hospital, Taipei, Taiwan (NTUH107-N004038) and the Ministry of Science and Technology, Taiwan (105-2628-B-002-011-MY2).


There are no conflicts of interest.

Supplementary material

10434_2018_6993_MOESM1_ESM.doc (35 kb)
Supplementary material 1 (DOC 35 kb)
10434_2018_6993_MOESM2_ESM.docx (222 kb)
Supplementary material 2 (DOCX 222 kb)


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© Society of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Department of SurgeryNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  2. 2.Graduate Institute of Pathology, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  3. 3.Department of PathologyNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  4. 4.Department of Internal MedicineNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan

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