Pleuropulmonary Recurrence Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Appendiceal Pseudomyxoma Peritonei

  • Joal D. Beane
  • Gregory C. Wilson
  • Jeffrey M. Sutton
  • Yongli Shuai
  • Lekshmi Ramalingam
  • Heather L. Jones
  • James F. PingpankII
  • Matthew P. Holtzman
  • Amer J. Zureikat
  • Steven A. Ahrendt
  • Herbert J. Zeh
  • David L. Bartlett
  • Haroon A. ChoudryEmail author
Peritoneal Surface Malignancy



The aim of this study was to identify factors associated with pleuropulmonary disease recurrence following cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) for appendiceal pseudomyxoma peritonei (PMP) and to evaluate the oncologic impact of pleuropulmonary disease recurrence compared with isolated peritoneal recurrence.


From a prospective database, we identified patients who developed pleuropulmonary recurrence, isolated peritoneal recurrence, or no recurrence following CRS/HIPEC for appendiceal PMP. Clinicopathologic, perioperative, and oncologic data associated with the index CRS/HIPEC procedure were reviewed. The Kaplan–Meier method was used to estimate survival. Multivariate analyses identified associations with recurrence and survival.


Of 382 patients undergoing CRS/HIPEC, 61 (16%) developed pleuropulmonary recurrence. Patients who developed a pleuropulmonary recurrence were more likely to have high-grade (American Joint Committee on Cancer [AJCC] grade 2/3) tumors (74% vs. 56%, p = 0.02) and increased operative blood loss (1651 vs. 1201 ml, p = 0.05) and were more likely to have undergone diaphragm stripping/resection (79% vs. 48%, p < 0.01) compared with patients with an abdominal recurrence. In a multivariate analysis, pleuropulmonary recurrence after CRS/HIPEC was associated with diaphragm stripping/resection, incomplete cytoreduction, and higher AJCC tumor grade. There was a trend towards reduced survival in patients with pleuropulmonary recurrence compared with patients with isolated peritoneal recurrence (median overall survival 45 vs. 53 months, p = 0.87).


Pleuropulmonary recurrence of appendiceal PMP following CRS/HIPEC is common and may negatively impact survival. Formal protocols for surveillance and therapeutic intervention need to be studied and implemented to improve oncologic outcomes.


Author’s Contribution

This study was designed and conceptualized by JDB and HAC; data were acquired by JDB, GCW, JMS, and LR; analysis and interpretation of the data was performed by JDB, YS, and HAC; and the manuscript was initially drafted by JDB and HAC, with critical revisions by GCW, JMS, YS, HLJ, JFP, MPH, AJZ, SAA, HJZ, and DLB.


Joal D. Beane, Gregory C. Wilson, Jeffrey M. Sutton, Yongli Shuai, Lekshmi Ramalingam, Heather L. Jones, James F. Pingpank II, Matthew P. Holtzman, Amer J. Zureikat, Steven A. Ahrendt, Herbert J. Zeh, David L. Bartlett, and Haroon A. Choudry have no conflicts of interest to declare.


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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Joal D. Beane
    • 1
  • Gregory C. Wilson
    • 1
  • Jeffrey M. Sutton
    • 1
  • Yongli Shuai
    • 2
  • Lekshmi Ramalingam
    • 1
  • Heather L. Jones
    • 1
  • James F. PingpankII
    • 1
  • Matthew P. Holtzman
    • 1
  • Amer J. Zureikat
    • 1
  • Steven A. Ahrendt
    • 3
  • Herbert J. Zeh
    • 4
  • David L. Bartlett
    • 1
  • Haroon A. Choudry
    • 1
    Email author
  1. 1.Division of Surgical OncologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  2. 2.The University of Pittsburgh Cancer Institute Biostatistics FacilityPittsburghUSA
  3. 3.Division of Surgical OncologyUniversity of Colorado School of MedicineAuroraUSA
  4. 4.University of Texas Southwestern Medical CenterDallasUSA

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