Advertisement

Annals of Surgical Oncology

, Volume 24, Supplement 3, pp 644–645 | Cite as

Reply: YAP is a Key Factor to Improve the Management of Cancer Treatments

  • Ping-Li Sun
  • Yan Jin
  • Jin-Haeng Chung
Hepatobiliary Tumors

Notes

Acknowledgement

This work was supported by the grants from the Korea Healthcare Technology R&D 340 Project, Ministry of Health and Welfare, Republic of Korea (HI14C1907), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2014-059757 to JHC).

References

  1. 1.
    Sun PL, Kim JE, Yoo SB, et al. Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment. Ann Surg Oncol. 2014;21 Suppl 4:S610–18.CrossRefPubMedGoogle Scholar
  2. 2.
    Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19:491–505.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes Dev. 2013;27:355–71.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Oren M, Aylon Y (2013) The Hippo signaling pathway and cancer. Springer, New York.CrossRefGoogle Scholar
  5. 5.
    Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421–34.CrossRefPubMedGoogle Scholar
  6. 6.
    Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120–33.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell. 2003;11:11–23.CrossRefPubMedGoogle Scholar
  8. 8.
    Harvey KF, Zhang X, Thomas DM. The Hippo pathway and human cancer. Nat Rev Cancer. 2013;13:246–57.CrossRefPubMedGoogle Scholar
  9. 9.
    Liu JY, Li YH, Lin HX, et al. Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer. 2013;13:349.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Xia Y, Chang T, Wang Y, et al. YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PLoS ONE. 2014;9:e91770.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Second Hospital of Jilin UniversityChangchunP.R. China
  2. 2.Department of PathologyFudan University Shanghai Cancer CenterShanghaiP.R. China
  3. 3.Department of PathologySeoul National University Bundang Hospital, Seoul National University College of MedicineSeongnamRepublic of Korea

Personalised recommendations