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Annals of Surgical Oncology

, Volume 25, Issue 1, pp 148–153 | Cite as

Pre-operative Axillary Ultrasound-Guided Needle Sampling in Breast Cancer: Comparing the Sensitivity of Fine Needle Aspiration Cytology and Core Needle Biopsy

  • Ashley R. Topps
  • Simon P. Barr
  • Panagiotis Pikoulas
  • Susan A. Pritchard
  • Anthony J. Maxwell
Breast Oncology

Abstract

Background

Pre-operative ultrasound-guided needle sampling (UNS) of abnormal axillary lymph nodes in breast cancer can identify patients with axillary metastases and therefore rationalize patient care and inform decision-making. To obtain tissue diagnosis, UNS can be performed by either fine needle aspiration (FNA) or core needle biopsy (CNB). However, few studies have compared the sensitivity of these techniques and the majority show no difference.

Methods

All node-positive patients (those with micro- and macrometastases but not isolated tumor cells) treated at a tertiary referral center between January 2012 and December 2015 were retrospectively identified from pathology records. The result of the first axillary UNS performed on each patient was compared with postoperative histopathology results. The UNS method used was according to individual radiologist preference.

Results

A total of 215 patients underwent FNA (1 patient had bilateral breast cancer and underwent bilateral FNA), and 92 underwent CNB. Sensitivity of CNB was significantly higher than FNA (83.7 vs. 69.0%, P = 0.008). The false-negative rate in the FNA group was therefore higher than in the CNB group by a factor of 2.5. There was no difference in inadequacy rate between the two techniques. There were no complications in the FNA group, and only one hematoma (which did not require operative intervention) in the CNB group.

Conclusions

CNB is safe and should be the preferred technique for UNS to improve sensitivity.

Notes

Acknowledgements

None declared.

Disclosure

None declared.

Financial Support

None declared.

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Copyright information

© Society of Surgical Oncology 2017

Authors and Affiliations

  • Ashley R. Topps
    • 1
    • 4
  • Simon P. Barr
    • 1
  • Panagiotis Pikoulas
    • 1
  • Susan A. Pritchard
    • 2
  • Anthony J. Maxwell
    • 1
    • 3
  1. 1.Nightingale CentreUniversity Hospital of South ManchesterManchesterUK
  2. 2.Department of HistopathologyUniversity Hospital of South ManchesterManchesterUK
  3. 3.School of Health SciencesUniversity of ManchesterManchesterUK
  4. 4.Burnley General HospitalBurnleyUK

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